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Dergiler / Experimed / 2022 / Cilt: 12 - Sayı: 2

The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity

Bertan Boran BAYRAK
Dastagul MAHMARZAYEVA
İsmet Burcu TÜRKYILMAZ
Özlem SAÇAN
Refiye YANARDAĞ
Sayfa
38–43
Yayın Tarihi
2022-08-22
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Consequently, it may be considered that MMSC has a protective role on brain in GalN-induced hepatotoxicity in rats

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: The objective of the current work is to examine the protective effects of S-methyl methionine sulfonium chloride (MMSC) on brain in galactosamine (GalN)-induced hepatotoxicity in rats.
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Temel Bulgular & Veri:Materials and Methods: A total of twenty two female Sprague-Dawley rats were randomly assigned into four groups as follows: Group I (n=5), intact control animals; Group II (n=6), animals that received 50 mg/kg/day of MMSC by gavage technique for 3 consecutive days; Group III (n=5), animals injected with a single dose of 500 mg/kg of GalN intraperitoneally (i.p.); and Group IV (n=6) are animals injected with the same dose of GalN (i.p.) 1 hour after MMSC treatment.
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Sonuç & Katkı:Conclusion: Consequently, it may be considered that MMSC has a protective role on brain in GalN-induced hepatotoxicity in rats
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Galactosamine · S-methyl methionine sulfonium chloride · brain

Abstract

Objective: The objective of the current work is to examine the protective effects of S-methyl methionine sulfonium chloride (MMSC) on brain in galactosamine (GalN)-induced hepatotoxicity in rats. Materials and Methods: A total of twenty two female Sprague-Dawley rats were randomly assigned into four groups as follows: Group I (n=5), intact control animals; Group II (n=6), animals that received 50 mg/kg/day of MMSC by gavage technique for 3 consecutive days; Group III (n=5), animals injected with a single dose of 500 mg/kg of GalN intraperitoneally (i.p.); and Group IV (n=6) are animals injected with the same dose of GalN (i.p.) 1 hour after MMSC treatment. At the end of the experiments (after 6 hours of the last GalN treatment), all animals were sacrificed under anaesthesia, and brain tissues were dissected out. Results: A statistically remarkable increase in lipid peroxidation, hydroxyproline, and nitric oxide levels, was detected while a notable decline in the activities of sodium/potassium ATPase was observed in GalN group in comparison with control rats. In contrast, all alterations observed were reversed when MMSC was given to GalN groups. Conclusion: Consequently, it may be considered that MMSC has a protective role on brain in GalN-induced hepatotoxicity in rats

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Bu Makaleye Atıf Yap

BAYRAK, B. B., MAHMARZAYEVA, D., TÜRKYILMAZ, İ. B., SAÇAN, Ö., YANARDAĞ, R. (2022). The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity. Experimed, Cilt: 12 - Sayı: 2, 38–43. https://ajindex.com/articles/665322

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Kaynakça (12)

  1. Singh G, Sharma R. Animal models for hepatoxicity. In: Sobti RC, editor. Advances in Animal Experimentation and Modeling. Aca-demic Press: London
  2. p.195-203. google scholar 2. Rouf A, Das AK, Khatoon MSTM, Mitu NL, Shahriar M. Evaluation of hepatoprotective effects of arogyavardhini against D-galac-tosamine-induced hepatotoxicity in rats. J Pharmacog Phyto-chem 2021
  3. 10(1): 12-9. google scholar 3. Dong W, Song E, Song Y. Co-administration of lipopolysaccharide and D-galactosamine induces genotoxicity in mouse liver. Sci Rep 2021
  4. [CrossRef] google scholar 4. Hajam YA, Rani R, Ganie SY, Sheikh TA, Javaid D, Qadri SS, et al. Oxidative stress in human pathology and aging: molecular mech-anisms and perspectives. Cells 2022
  5. 11(3): 552. [CrossRef] google scholar 5. Anwar MM. Oxidative stress-a direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease. Cell Biochem Funct 2022
  6. 40(1): 17-27. [CrossRef] google scholar 6. Choi EH, Lee SB, Lee DY, Kim GT, Shim SM, Park TS. Increased in-testinal absorption of vitamin U in steamed graviola leaf extract activates nicotine detoxification. Nutrients 2019
  7. 11(6): 1334. [CrossRef] google scholar 7. Oktay S, Bayrak G, Alev B, Ipekci H, Ustundag UV, Turkyilmaz IB, et al. The effect of vitamin U on the lung tissue of pentylenetera-zole-induced seizures in rats. Naunyn-Schmiedeberg's Arch Phar-macol 2018
  8. 391(2): 177-84. [CrossRef] google scholar 8. Gezginci-Oktayoglu S, Turkyilmaz IB, Ercin M, Yanardag R, Bolkent S. Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fi-brotic properties. Protoplasma 2016
  9. 253(1): 127-35. [CrossRef] google scholar 9. Bayrak BB, Catal T, Oztay F, Yanardag R, Bolkent S. Efficacy of anti-oxidant vitamins (vitamin C, vitamin E, beta-carotene) and seleni-um supplement on D-galactosamine-induced lung injury. IUFS J Biol 2016
  10. 75(1): 11-8. google scholar 10. Ledwozyw A, Michalak J, Stepien A, Kadziolka A. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin Chim Acta 1986
  11. [CrossRef] google scholar 11. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996
  12. 22529. [CrossRef] google scholar 12. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophoto-metric method for simultaneous detection of nitrate and nitrite.