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Dergiler / Turkish Journal of Biology / 2017 / Cilt: 41 - Sayı: 5

N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering

Murat DEMİRBİLEK
Selçuk AKTÜRK
Nelisa LAÇİN TÜRKOĞLU
Sayfa
796–807
Yayın Tarihi
2022-11-05
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It stimulated IL-10 and TNF-alpha levels at a small rate.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In the treatment of dermal wounds, wound-dressing materials prepared from natural mucopolysaccharides are widely used because of their advantages such as nonirritation, nontoxicity, and ease in topical application.
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Temel Bulgular & Veri:Anti- and proinflammatory cytokine levels of human monocyte-macrophage cells (THP-1) stimulated with hydrogels were determined.
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Sonuç & Katkı:It stimulated IL-10 and TNF-alpha levels at a small rate.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In the treatment of dermal wounds, wound-dressing materials prepared from natural mucopolysaccharides are widely used because of their advantages such as nonirritation, nontoxicity, and ease in topical application. In the present study, alginate hydrogels modified with N-acetyl glucose amine (NAG) were prepared as wound-dressing material. Physical, chemical, thermal, and mechanical properties of the hydrogels were studied. Cytotoxicity of the hydrogels on endothelial (HUVEC) and keratinocyte (HaCaT) cells were examined. Anti- and proinflammatory cytokine levels of human monocyte-macrophage cells (THP-1) stimulated with hydrogels were determined. According to the results, increasing the NAG concentration led to an increase in the swelling and nitrogen ratios in the hydrogels. Additionally, increasing the NAG concentration decreased elastic modulus and degradation time. Hydrogels were not cytotoxic on HaCaT and HUVEC cells. It stimulated IL-10 and TNF-alpha levels at a small rate.

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Bu Makaleye Atıf Yap

DEMİRBİLEK, M., AKTÜRK, S., TÜRKOĞLU, N. L. (2022). N-Acetylglucoseamine modified alginate sponges as scaffolds for skin tissue engineering. Turkish Journal of Biology, Cilt: 41 - Sayı: 5, 796–807. https://ajindex.com/articles/654406

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Kaynakça (14)

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