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Dergiler / Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi / 2020 / Cilt: 7 - Sayı: 2

Synthesis and Characterization of New Compounds Including Propargyl Side Chain as Potential MAO-B Inhibitor

Potansiyel MAO-B İnhibitörü Olarak Propargil Yan Zinciri İçeren Yeni Bileşiklerin Sentezi ve Karakterizasyonu

Derya OSMANİYE
Yusuf ÖZKAY
Sayfa
755–763
Yayın Tarihi
2022-11-06
DOI
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Activity studies revealed that synthesis compounds inhibited MAO enzymes to different extends..

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, some new propargyl derivatives were synthesized considering potential monoamine oxidase-B (MAO-B) inhibition potency of propargyl moiety.
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Temel Bulgular & Veri:In synthesis studies, 2-chlorobenzimidazole was reacted with propargyl bromide in the presence of NaH and compound 1 was obtained.
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Sonuç & Katkı:Activity studies revealed that synthesis compounds inhibited MAO enzymes to different extends..
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

In this study, some new propargyl derivatives were synthesized considering potential monoamine oxidase-B (MAO-B) inhibition potency of propargyl moiety. In synthesis studies, 2-chlorobenzimidazole was reacted with propargyl bromide in the presence of NaH and compound 1 was obtained. Compound 1 was treated with various benzylamine derivatives and final products (2a-2c) were gained. Structures of obtained compounds were established by spectroscopic methods. Effects of the synthesized compounds against MAO enzymes were observed by using in-vitro fluorimetric method. Activity studies revealed that synthesis compounds inhibited MAO enzymes to different extends..

Abstract

Bu çalışma kapsamında, propargil grubunun Monoaminoksidaz-B (MAO-B) enzimi üzerindeki potansiyel inhibitör etkinliği dikkate alınarak bazı yeni propargil grubu içeren bileşikler sentezlenmiştir. Sentez çalışmalarında, 2- klorobenzimidazol NaH varlığında propargil bromür ile reaksiyona sokulmuş bileşik 1 elde edilmiştir. Bileşik 1 çeşitli benzilamin türevleri ile potasyum karbonat katalizörlüğünde muamele edilerek sonuç ürünlerine (2a-2c) ulaşılmıştır. Elde edilen bileşiklerin yapıları 1HNMR ve 13C-NMR ve HRMS spektroskopik yöntemleri ile doğrulanmıştır. Sentezlenen bileşiklerin MAO enzimleri üzerindeki etkileri in-vitro şartlarda florimetrik yöntem kullanılarak araştırılmıştır. Yapılan aktivite çalışmaları sonucunda sentezlenen bileşiklerin MAO enzimlerini değişen düzeylerde inhibe ettiği tespit edilmiştir.

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Bu Makaleye Atıf Yap

OSMANİYE, D., ÖZKAY, Y. (2022). Synthesis and Characterization of New Compounds Including Propargyl Side Chain as Potential MAO-B Inhibitor. Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, Cilt: 7 - Sayı: 2, 755–763. https://ajindex.com/articles/649098

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Kaynakça (12)

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