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Dergiler / Turkish Neurosurgery / 2018 / Cilt: 28 - Sayı: 4

Which is Better: Stainless Steel or Titanium Alloy?

Suzan ADIN CINAR
Hakan BOZKUS
Mehmet Murat HANCI
Sibel AKYOL
Sayfa
630–635
Yayın Tarihi
2022-11-05
DOI
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There wasa reduction in IL-6 and IL-17A levels in Group II as opposed to Group I.CONCLUSION: As opposed to SS alloy, Ti alloy suppresses the development of inflammation by inhibiting the pro-inflammatoryresponse; strengthens the humoral immune system by intensifying the antibody-dependent immune response; triggers thedevelopment of immune tolerance by regulating the immune response; and activates the mechanism that prevents immuneresponse-related damage from occurring.

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Amaç & Hipotez:AIM: To investigate immunologic reactions after implantation of stainless steel (SS) alloy and titanium (Ti) alloy in a rat model.Macrophage and cytokine responses have been reported after in vivo and in vitro application of different biomaterials.MATERIAL and METHODS: Wistar albino rats were used.
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Temel Bulgular & Veri:The CD4, CD8, CD25 (IL-2R) (lymphocyte and CD4 gate), CD4+CD8+ and CD4+CD25+Foxp3+ (Tregs), IL-4, IL-10,IL-6, IL-17A, TGF-β,TNF-α in the blood were analyzed.RESULTS: CD4, CD25 (IL-2R), CD4+CD8+ and Tregs levels were lower in Group III compared to Group I (sham) and Group II.
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Sonuç & Katkı:There wasa reduction in IL-6 and IL-17A levels in Group II as opposed to Group I.CONCLUSION: As opposed to SS alloy, Ti alloy suppresses the development of inflammation by inhibiting the pro-inflammatoryresponse; strengthens the humoral immune system by intensifying the antibody-dependent immune response; triggers thedevelopment of immune tolerance by regulating the immune response; and activates the mechanism that prevents immuneresponse-related damage from occurring.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

AIM: To investigate immunologic reactions after implantation of stainless steel (SS) alloy and titanium (Ti) alloy in a rat model.Macrophage and cytokine responses have been reported after in vivo and in vitro application of different biomaterials.MATERIAL and METHODS: Wistar albino rats were used. After an exploration of the thoracolumbar paravertebral muscle tissueof the subjects, Group I underwent sham surgery, and Groups II and III underwent implantation of Ti alloy and SS alloy rodsrespectively. The CD4, CD8, CD25 (IL-2R) (lymphocyte and CD4 gate), CD4+CD8+ and CD4+CD25+Foxp3+ (Tregs), IL-4, IL-10,IL-6, IL-17A, TGF-β,TNF-α in the blood were analyzed.RESULTS: CD4, CD25 (IL-2R), CD4+CD8+ and Tregs levels were lower in Group III compared to Group I (sham) and Group II. IL-6,IL-17A, TGF-β and TNF-α levels in Group III showed a significant increase on all days in comparison with Group I and Group II. IL-4and IL-10 levels were lower in Group III than those in Group II; and a significant decrease was observed in the IL-10 level. There wasa reduction in IL-6 and IL-17A levels in Group II as opposed to Group I.CONCLUSION: As opposed to SS alloy, Ti alloy suppresses the development of inflammation by inhibiting the pro-inflammatoryresponse; strengthens the humoral immune system by intensifying the antibody-dependent immune response; triggers thedevelopment of immune tolerance by regulating the immune response; and activates the mechanism that prevents immuneresponse-related damage from occurring.

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Bu Makaleye Atıf Yap

CINAR, S. A., BOZKUS, H., HANCI, M. M., AKYOL, S. (2022). Which is Better: Stainless Steel or Titanium Alloy?. Turkish Neurosurgery, Cilt: 28 - Sayı: 4, 630–635. https://ajindex.com/articles/616984

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Kaynakça (13)

  1. Albrektsson T, Hansson HA: An ultrastructural characterization of the interface between bone and sputtered titanium or stainless steel surfaces. Biomaterials 7:201-205, 1986
  2. Arens S, Schlegel U, Printzen G, Ziegler WJ, Perren SM, Hansis M: Influence of materials for fixation implants on local infection. An experimental study of steel versus titanium DCP in rabbits. J Bone Joint Surg Br 78:647-651,1996
  3. Arora A, Song Y, Chun L, Huie P, Trindade M, Smith RL, Goodman S: The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements. J Biomed Mater Res Part A 64:693-697, 2003
  4. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238, 2006
  5. Borish LC, Steinke JW: Cytokines and chemokines. J Allergy Clin Immunol 111: 460-475, 2003
  6. Daley B, Doherty AT, Fairman B, Case CB: Wear debris from hip or knee replacements causes chromosomal damage in human cells in tissue culture. J Bone Joint Surg Br 86-B:598- 606, 2004
  7. Giertz SH, Fernandes BL, Fernandes CR, Franco CRC: Metallic ions in organs of rats injected with metallic particles of stainless steel 316L and Ti6Al4V alloy. Mat Res 13:35-39, 2010
  8. Gregori S, Bacchetta R, Passerini L, Levings MK, Roncarolo M: Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol Biol 380: 83-105,2007 Hanawa T: Metal ion release from metal implants. Mater Sci Eng C 24: 745-752, 2004
  9. Im GI, Han JD: Suppressive effects of interleukin-4 and interleukin-10 on the production of proinflammatory cytokines induced by titanium-alloy particles. J Biomed Mater Res 58: 531-536, 2001
  10. Jovanovic DV, Battista JAD, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, Mineau F, Pelletier JP: IL-17 stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages. J Immunol 160:3513- 3521,1998
  11. Katou F, Andoh N, Motegi K, Nagura H: Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures. J Cranio-Maxillofac Surg 24:155-162,1996
  12. Majetschak M, Bardenheuer M, Obertacke U: Immunoinflammatory tissue reaction to stainless-steel and titanium plates used for internal fixation of long bones. Biomaterials 24:247-254, 2003
  13. Miyara M, Sakaguchi S: Natural regulatory T cells: Mechanisms of suppression. Trends Mol Med 13:108-116, 2007