It was determined that neuron andneuroglial cell TUNEL staining was statistically different among the three groups (p
📌 3 Maddede Bu Makale
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Amaç & Hipotez:AIM: To investigate the effects of fluorescein-sodium on neural tissues.MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) andfluorescein-sodium groups with different doses (groups 2 and 3).
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Temel Bulgular & Veri:In the study groups, the opendura was covered with a sponge soaked with 0.02 mg (group 2) and with 0.2 mg (group 3) fluorescein sodium following craniectomy.Three weeks postoperatively, rats were sacrificed for the histopathologic evaluations.RESULTS: Fluorescein-induced apoptosis occurs in a dose-dependent manner in rats’ neurons.
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Sonuç & Katkı:It was determined that neuron andneuroglial cell TUNEL staining was statistically different among the three groups (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
AIM: To investigate the effects of fluorescein-sodium on neural tissues.MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) andfluorescein-sodium groups with different doses (groups 2 and 3). In the control group, craniectomy following with durotomy wasperformed with the help of a loupe microscope, and a dry sponge was overlayed to the brain tissue. In the study groups, the opendura was covered with a sponge soaked with 0.02 mg (group 2) and with 0.2 mg (group 3) fluorescein sodium following craniectomy.Three weeks postoperatively, rats were sacrificed for the histopathologic evaluations.RESULTS: Fluorescein-induced apoptosis occurs in a dose-dependent manner in rats’ neurons. It was determined that neuron andneuroglial cell TUNEL staining was statistically different among the three groups (p
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Bu Makaleye Atıf Yap
BUHUR, A., YIGITTURK, G., OZER, F., GAZIOGLU, N., OLTULU, F., CAMLAR, M., TURK, C., OREN, M. (2022). How Safe is the Use of Intrathecal Fluorescein? An Experimental Study. Turkish Neurosurgery, Cilt: 29 - Sayı: 4, 549–554. https://ajindex.com/articles/616913
Acikgoz E, Aktug H, Yigitturk G, Demir K, Guven U, Duzagac F, Oltulu F, Yavasoglu A, Oktem G: Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice. Folia Histochem Cytobiol 55:140-148, 2017 2. Akcay E, Ersahin Y, Ozer F, Duransoy YK, Camlar M, Atci I, Yagci A, Ozer O: Neurotoxic effect of povidone-iodine on the rat spine using a laminectomy-durotomy model. Childs Nerv Syst 28:2071-2075, 2012 3. Anari S, Waldron M, Carrie S: Delayed absence seizure: A complication of intrathecal fluorescein injection. A case report and literature review. Auris Nasus Larynx 34:515-518, 2007 4. Fishman AJ, Hoffman RA, Roland JT Jr, Lebowitz RA, Cohen NL: CSF drainage in the management of CSF leak following acoustic neuroma surgery. Laryngoscope 106:1002–1004, 1996 5. Ghosh S, Karin M: Missing pieces in the NF-kappa B puzzle. Cell 109 Suppl:81-96, 2002 6. Jacob AK, Dilger JA, Hebl JR: Status epilepticus and intrathecal fluorescein: Anesthesia providers beware. Anesth Analg 107:229-231, 2008 7. Jones ME, Reino T, Gnoy A, Guillory S, Wackym Pi, Lawson W: Identification of intranasal cerebrospinal fluid leaks by topical application with fluorescein dye. Am J Rhinol 14:93–96, 2000 8. Karin M, Lin A: NF-κβ at the crossroads of life and death. Nat Immunol 3:221–227, 2002 9. Keerl R, Weber RK, Draf W, Radziwill R, Wienke A: Complications of lumbar administration of 5% sodium fluorescein solution for detection of cerebrospinal fluid fistula. Laryngorhinootologie 82:833-838, 2003 10. Keerl R, Weber RK, Draf W, Wienke A, Schaefer SD: Use of sodium fluorescein solution for detection of cerebrospinal fluid fistulas: An analysis of 420 administrations and reported complications in Europe and the United States. Laryngoscope 114:266-272, 2004 11. Kerr JT, Chu FW, Bayles SW: Cerebrospinal fluid rhinorrhoea: Diagnosis and management. Otolaryngol Clin North Am 38:597-611, 2005 12. Marshall AH, Jones NS, Robertson IJ: CSF rhinorrhoea: The place of endoscopic surgery. Br J Neurosurg 15:8–12, 2001 13. Nandapalan V, Watson ID, Swift AC: Beta 2 transferrin and cerebrospinal fluid rhinorrhoea. Clin Otolaryngol Allied Sci 21:259-264, 1996 14. Oktem G, Uysal A, Oral O, Sezer ED, Olukman M, Erol A, Akgur SA, Bilir A: Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis. Experimental and Toxicologic Pathology 64:471-479, 2010 15. Puliyappadamba VT, Hatanpaa KJ, Chakraborty S, Chakraborty S, Habib AA: The role of NF