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Dergiler / Turkish Journal of Veterinary and Animal Sciences / 2016 / Cilt: 40 - Sayı: 1

Immunohistochemical evaluation of canine and felineMerkel cell tumors a report of two cases

Mateusz MIKIEWICZ
Iwona DOMAGALA OTROCKA
Katarzyna CZAPULA PAZDZIOR
Anna MIKOLAJCZYK
Agnieszka BLACHA
Michal GESEK
Sayfa
124–129
Yayın Tarihi
2022-11-05
DOI
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In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Merkel cell tumors, a type of cutaneous round-cell tumors, are rarely observed in dogs and cats.
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Temel Bulgular & Veri:In the present study, the morphology of canine and feline Merkel cell tumors and their immunoexpression of neuron-specific enolase, cytokeratin, chromogranin A, Ki67, and metallothionein were evaluated using histopathological and immunohistochemical methods.
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Sonuç & Katkı:In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Merkel cell tumors, a type of cutaneous round-cell tumors, are rarely observed in dogs and cats. This tumor type originates from cutaneous neuroendocrine cells. In the present study, the morphology of canine and feline Merkel cell tumors and their immunoexpression of neuron-specific enolase, cytokeratin, chromogranin A, Ki67, and metallothionein were evaluated using histopathological and immunohistochemical methods. The canine Merkel cell tumor displayed a diffuse morphological pattern, whereas the feline tumor displayed a solid morphological pattern. Both tumors were positive for neuron-specific enolase and cytokeratin, but negative for chromogranin A. The Ki67 indexes in the canine and feline tumors were 7% and 25%, respectively. The expression of metallothionein was minimal in both tumors. In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.

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Bu Makaleye Atıf Yap

MIKIEWICZ, M., OTROCKA, I. D., PAZDZIOR, K. C., MIKOLAJCZYK, A., BLACHA, A., GESEK, M. (2022). Immunohistochemical evaluation of canine and felineMerkel cell tumors a report of two cases. Turkish Journal of Veterinary and Animal Sciences, Cilt: 40 - Sayı: 1, 124–129. https://ajindex.com/articles/615141

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Kaynakça (15)

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