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Journals / Turkish Journal of Veterinary and Animal Sciences / 2016 / Cilt: 40 - Sayı: 1

Immunohistochemical evaluation of canine and felineMerkel cell tumors a report of two cases

Mateusz MIKIEWICZ
Iwona DOMAGALA OTROCKA
Katarzyna CZAPULA PAZDZIOR
Anna MIKOLAJCZYK
Agnieszka BLACHA
Michal GESEK
Pages
124–129
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.

📌 3 Key Takeaways

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Objective & Hypothesis:Merkel cell tumors, a type of cutaneous round-cell tumors, are rarely observed in dogs and cats.
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Key Findings & Data:In the present study, the morphology of canine and feline Merkel cell tumors and their immunoexpression of neuron-specific enolase, cytokeratin, chromogranin A, Ki67, and metallothionein were evaluated using histopathological and immunohistochemical methods.
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Conclusion & Impact:In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Merkel cell tumors, a type of cutaneous round-cell tumors, are rarely observed in dogs and cats. This tumor type originates from cutaneous neuroendocrine cells. In the present study, the morphology of canine and feline Merkel cell tumors and their immunoexpression of neuron-specific enolase, cytokeratin, chromogranin A, Ki67, and metallothionein were evaluated using histopathological and immunohistochemical methods. The canine Merkel cell tumor displayed a diffuse morphological pattern, whereas the feline tumor displayed a solid morphological pattern. Both tumors were positive for neuron-specific enolase and cytokeratin, but negative for chromogranin A. The Ki67 indexes in the canine and feline tumors were 7% and 25%, respectively. The expression of metallothionein was minimal in both tumors. In conclusion, this paper describes the detailed histopathological and immunohistochemical features of uncommon canine and feline Merkel cell tumors, including metallothionein expression, which has never been studied in such tumors pre v i ou s ly.

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Cite This Article

MIKIEWICZ, M., OTROCKA, I. D., PAZDZIOR, K. C., MIKOLAJCZYK, A., BLACHA, A., GESEK, M. (2022). Immunohistochemical evaluation of canine and felineMerkel cell tumors a report of two cases. Turkish Journal of Veterinary and Animal Sciences, Cilt: 40 - Sayı: 1, 124–129. https://ajindex.com/articles/615141

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References (15)

  1. Lowell DL, Roberts J, Gogate P, Goodwin R. Merkel cell carcinoma: case study and literature review. J Foot Ankle Surg 2014; 53: 219–225
  2. Munde PB, Khandekar SP, Dive AM, Sharma A. Pathophysiology of Merkel cell. J Oral Maxillofac Pathol 2013; 17: 408–412
  3. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat. Clinical and Histopathologic Diagnosis. 2nd ed. Oxford, UK: Blackwell Publishing; 2005
  4. Bagnasco G, Properzi R, Porto R, Nardini V, Poli A, Abramo F. Feline cutaneous neuroendocrine carcinoma (Merkel cell tumour): clinical and pathological findings. Vet Dermatol 2003; 14: 111–115
  5. Joiner KS, Smith AN, Henderson RA, Brawner WR, Spangler EA, Sartin EA. Multicentric cutaneous neuroendocrine (Merkel cell) carcinoma in a dog. Vet Pathol 2010; 47: 1090–1094
  6. Konno A, Nagata M, Nanko H. Immunohistochemical diagnosis of a Merkel cell tumor in a dog. Vet Pathol 1998; 35: 538–540
  7. Cherian MG, Apostolova MD. Nuclear localization of metallothionein during cell proliferation and differentiation. Cell Mol Biol (Noisy-le-grand) 2000; 46: 347–356
  8. Pattanaik A, Shaw CF 3rd, Petering DH, Garvey J, Kraker AJ. Basal metallothionein in tumors: widespread presence of apoprotein. J Inorg Biochem 1994; 54: 91–105
  9. Martano M, Carella F, Squillacioti C, Restucci B, Mazzotta M, Lo Muzio L, Maiolino P. Metallothionein expression in canine cutaneous apocrine gland tumors. Anticancer Res 2012; 32: 747–752
  10. Dincer Z, Jasani B, Haywood S, Mullins JE, Fuentealba IC. Metallothionein expression in canine and feline mammary and melanotic tumours. J Comp Pathol 2001; 125: 130–136
  11. Gumulec J, Raudenska M, Adam V, Kizek R, Masarik M. Metallothionein – immunohistochemical cancer biomarker: a meta-analysis. PLoS One 2014; 9: e85346
  12. Werynska B, Pula B, Muszczynska-Bernhard B, Piotrowska A, Jethon A, Podhorska-Okolow M, Dziegiel P, Jankowska R. Correlation between expression of metallothionein and expression of Ki-67 and MCM-2 proliferation markers in non-small cell lung cancer. Anticancer Res 2011; 31: 2833–2839
  13. Kim JS, Jung J, Lee HJ, Kim JC, Wang H, Kim SH, Shin T, Moon C. Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochem 2009; 111: 150–156
  14. Gil da Costa RM, Rema A, Pires MA, Gärtner F. Two canine Merkel cell tumours: immunoexpression of c-KIT, E-cadherin, beta-catenin and S100 protein. Vet Dermatol 2010; 21: 198–201
  15. Jirásek T, Matej R, Poc