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Dergiler / Turkish Journal of Medical Sciences / 2004 / Cilt: 34 - Sayı: 5

Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection

Hasan DOĞAN
Hatice ODABAŞ
Mevlit İKBAL
İbrahim PİRİM
Sayfa
309–313
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine.
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Temel Bulgular & Veri:Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001).
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Sonuç & Katkı:The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Ciprofloxacin · sister chromatid exchange · mitotic index

Özet

Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine. The genotoxicity of ciprofloxacin was evaluated in cultured human peripheral blood lymphocytes in patients with urinary tract infection. Sister chromatid exchange (SCE), mitotic index (MI) and replicative index (RI) were measured before and after ciprofloxacin therapy. Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001). The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

Abstract

Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine. The genotoxicity of ciprofloxacin was evaluated in cultured human peripheral blood lymphocytes in patients with urinary tract infection. Sister chromatid exchange (SCE), mitotic index (MI) and replicative index (RI) were measured before and after ciprofloxacin therapy. Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001). The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

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Bu Makaleye Atıf Yap

DOĞAN, H., ODABAŞ, H., İKBAL, M., PİRİM, İ. (2022). Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection. Turkish Journal of Medical Sciences, Cilt: 34 - Sayı: 5, 309–313. https://ajindex.com/articles/612052

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