SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2004 / Cilt: 34 - Sayı: 5

Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection

Hasan DOĞAN
Hatice ODABAŞ
Mevlit İKBAL
İbrahim PİRİM
Pages
309–313
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine.
📊
Key Findings & Data:Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001).
💡
Conclusion & Impact:The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ciprofloxacin · sister chromatid exchange · mitotic index

Abstract

Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine. The genotoxicity of ciprofloxacin was evaluated in cultured human peripheral blood lymphocytes in patients with urinary tract infection. Sister chromatid exchange (SCE), mitotic index (MI) and replicative index (RI) were measured before and after ciprofloxacin therapy. Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001). The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

Özet

Ciprofloxacin is a quinolone carboxylic acid derivative and is commonly used in medicine. The genotoxicity of ciprofloxacin was evaluated in cultured human peripheral blood lymphocytes in patients with urinary tract infection. Sister chromatid exchange (SCE), mitotic index (MI) and replicative index (RI) were measured before and after ciprofloxacin therapy. Our results showed that SCE frequency significantly increased after ciprofloxacin therapy (P < 0.001), but MI and RI decreased (P < 0.001). The results of this study suggest that clinical therapy using ciprofloxacin may have a moderate genotoxic potential.

🔖

Cite This Article

DOĞAN, H., ODABAŞ, H., İKBAL, M., PİRİM, İ. (2022). Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection. Turkish Journal of Medical Sciences, Cilt: 34 - Sayı: 5, 309–313. https://ajindex.com/articles/612052

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...