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Dergiler / Turkish Journal of Medical Sciences / 2007 / Cilt: 37 - Sayı: 1

Orta karadeniz bölgesi sağlıklı Türk populasyonunda CCRSdelta32 frekansı

The frequency of CCRSdelta32 polymorphism in the central black sea coastal region in a healthy population

Nurten KARA
Hasan BAĞCI
Sezgin Özgür GÜNEŞ
Sayfa
17–19
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusions: Our data indicate that the low frequency of CCR5delta32 allele may be related to higher genetic susceptibility to HIV-1 infection in the central Black Sea coastal r

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: Delta32 polymorphism in the chemokine receptor 5 (CCR5) gene affects human immune deficiency virus type 1 (HIV-1) entry, transmission, and outcome.
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Temel Bulgular & Veri:The aim of this study was to determine the allelic frequencies of genetic variant CCR5delta32, which influence susceptibility to HIV-1 infection, in a northern Turkish population.
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Sonuç & Katkı:Conclusions: Our data indicate that the low frequency of CCR5delta32 allele may be related to higher genetic susceptibility to HIV-1 infection in the central Black Sea coastal r
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Aim: Delta32 polymorphism in the chemokine receptor 5 (CCR5) gene affects human immune deficiency virus type 1 (HIV-1) entry, transmission, and outcome. The aim of this study was to determine the allelic frequencies of genetic variant CCR5delta32, which influence susceptibility to HIV-1 infection, in a northern Turkish population. Materials and Methods: We determined the allelic frequencies of CCR5delta32 in 449 unrelated healthy individuals from the central Black Sea coastal region without any known history of HIV-1 infection. The polymorphism was analyzed using polymerase chain reaction (PCR). The population was in the Hardy- Weinberg equilibrium. Delta32 allelic frequencies were calculated. Results: The frequency of mutant delta32 allele in this population was 5.2%. Conclusions: Our data indicate that the low frequency of CCR5delta32 allele may be related to higher genetic susceptibility to HIV-1 infection in the central Black Sea coastal r

Abstract

Aim: Delta32 polymorphism in the chemokine receptor 5 (CCR5) gene affects human immune deficiency virus type 1 (HIV-1) entry, transmission, and outcome. The aim of this study was to determine the allelic frequencies of genetic variant CCR5delta32, which influence susceptibility to HIV-1 infection, in a northern Turkish population. Materials and Methods: We determined the allelic frequencies of CCR5delta32 in 449 unrelated healthy individuals from the central Black Sea coastal region without any known history of HIV-1 infection. The polymorphism was analyzed using polymerase chain reaction (PCR). The population was in the Hardy- Weinberg equilibrium. Delta32 allelic frequencies were calculated. Results: The frequency of mutant delta32 allele in this population was 5.2%. Conclusions: Our data indicate that the low frequency of CCR5delta32 allele may be related to higher genetic susceptibility to HIV-1 infection in the central Black Sea coastal r

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Bu Makaleye Atıf Yap

KARA, N., BAĞCI, H., GÜNEŞ, S. Ö. (2022). Orta karadeniz bölgesi sağlıklı Türk populasyonunda CCRSdelta32 frekansı. Turkish Journal of Medical Sciences, Cilt: 37 - Sayı: 1, 17–19. https://ajindex.com/articles/611820

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Kaynakça (10)

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