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Dergiler / Turkish Journal of Medical Sciences / 2010 / Cilt: 40 - Sayı: 3

Does melatonin alleviate cold preservation injury of the liver?

Ömer GÜNAL
Arif ASLANER
Abdurrahman COŞKUN
Ümran YILDIRIM
Sayfa
465–470
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 h.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:To investigate the effect of melatonin added to preservation solution on liver cold ischemia.
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Temel Bulgular & Veri:The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h.
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Sonuç & Katkı:Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 h.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Key words: Antioxidant · cold preservation · heat shock protein

Özet

To investigate the effect of melatonin added to preservation solution on liver cold ischemia. Materials and methods: Twenty male Wistar albino rats were divided equally into groups treated with University of Wisconsin (UW) solution with and without melatonin. The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h. Tissue malondialdehyde and heat shock protein (HSP 70) levels were also measured and a histological examination was performed at 48 h. Results: Melatonin prevented enzyme elevation, induced heat shock protein (HSP 70), and decreased lipid peroxidation effectively in comparison to the control group (P < 0.05). The histological examination revealed that UW solution containing melatonin prevented Kupffer cell activation and inflammation significantly (P < 0.05). Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 h.

Abstract

To investigate the effect of melatonin added to preservation solution on liver cold ischemia. Materials and methods: Twenty male Wistar albino rats were divided equally into groups treated with University of Wisconsin (UW) solution with and without melatonin. The LDH, AST, and ACP activities of the preservation solutions were determined in samples collected at 2, 24, 36, and 48 h. Tissue malondialdehyde and heat shock protein (HSP 70) levels were also measured and a histological examination was performed at 48 h. Results: Melatonin prevented enzyme elevation, induced heat shock protein (HSP 70), and decreased lipid peroxidation effectively in comparison to the control group (P < 0.05). The histological examination revealed that UW solution containing melatonin prevented Kupffer cell activation and inflammation significantly (P < 0.05). Conclusion: Melatonin in preservation solutions such as UW solution may protect tissue effectively from damage during cold ischemia for up to 48 h.

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Bu Makaleye Atıf Yap

GÜNAL, Ö., ASLANER, A., COŞKUN, A., YILDIRIM, Ü. (2022). Does melatonin alleviate cold preservation injury of the liver?. Turkish Journal of Medical Sciences, Cilt: 40 - Sayı: 3, 465–470. https://ajindex.com/articles/611535

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Kaynakça (13)

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