Higher neutrophil to lymphocyte ratio is related to a lower ejection fraction in bicuspid aortic valve patients

Results: When the results were compared, it was demonstrated that there was a positive correlation between NLR and ascending aorta diameter (r: 0.485, P = 0.026), whereas there was a negative correlation between NLR and left ventricular end-diastolic diameter (r: 0.475, P = 0.030), left ventricular end-systolic diameter (r: 0.482, P = 0.027), and left ventricular ejection fraction (r: 0.467, P = 0.033) in BAV patients with ascending aorta dilatation (group 1).

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: Inflammation plays an important role in the pathophysiology of vascular disease.

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Temel Bulgular & Veri:The subjects were separated into two groups based on their ascending aorta diameter.

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Sonuç & Katkı:Results: When the results were compared, it was demonstrated that there was a positive correlation between NLR and ascending aorta diameter (r: 0.485, P = 0.026), whereas there was a negative correlation between NLR and left ventricular end-diastolic diameter (r: 0.475, P = 0.030), left ventricular end-systolic diameter (r: 0.482, P = 0.027), and left ventricular ejection fraction (r: 0.467, P = 0.033) in BAV patients with ascending aorta dilatation (group 1).

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Background/aim: Inflammation plays an important role in the pathophysiology of vascular disease. In this study, we aimed to evaluate the associations of neutrophil to lymphocyte ratio (NLR; an indicator of inflammation) with left ventricular ejection fraction and ascending aorta diameter in patients with a bicuspid aortic valve (BAV). Materials and methods: One hundred and thirty-nine consecutive patients with the diagnosis of BAV were enrolled in the study. Complete blood counts were analyzed for neutrophil and lymphocyte levels and NLR. The subjects were separated into two groups based on their ascending aorta diameter. The patients with ascending aorta diameter equal to or above 3.9 cm were included in group 1 whereas those with ascending aorta diameter below 3.9 cm were included in group 2. Results: When the results were compared, it was demonstrated that there was a positive correlation between NLR and ascending aorta diameter (r: 0.485, P = 0.026), whereas there was a negative correlation between NLR and left ventricular end-diastolic diameter (r: 0.475, P = 0.030), left ventricular end-systolic diameter (r: 0.482, P = 0.027), and left ventricular ejection fraction (r: 0.467, P = 0.033) in BAV patients with ascending aorta dilatation (group 1).

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Bu Makaleye Atıf Yap

DURMAZ, T., ASLAN, A. N., AKÇAY, M., AYHAN, H., KELEŞ, T., KASAPKARA, H. A., TURİNAY, Z. Ş., GÜNEY, M. C., BOZKURT, E. (2022). Higher neutrophil to lymphocyte ratio is related to a lower ejection fraction in bicuspid aortic valve patients. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 4, 1144–1150. https://ajindex.com/articles/610698

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Kaynakça (12)

Verma S, Siu SC. Aortic dilatation in patients with bicuspid aortic valve. N Engl J Med 2014; 370: 1920-1929
Alegret JM, Palazón O, Duran I, Vernis JM. Aortic valve morphology definition with transthoracic combined with transesophageal echocardiography in a population with high prevalence of bicuspid aortic valve. Int J Cardiovasc Imaging 2005; 21: 213-217
Milan A, Tosello F, Naso D, Avenatti E, Leone D, Magnino C, Veglio F. Ascending aortic dilatation, arterial stiffness and cardiac organ damage in essential hypertension. J Hypertens 2013; 31: 109-116
Michelena HI, Khanna AD, Mahoney D, Margaryan E, Topilsky Y, Suri RM, Eidem B, Edwards WD, Sundt TM, EnriquezSarano M. Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 2011; 306: 1104-1112
Alegret JM, Ligero C, Vernis JM, Beltrán-Debón R, Aragonés G, Duran I, Palazón O, Hernández-Aparicio A. Factors related to the need for surgery after the diagnosis of bicuspid aortic valve: one center´s experience under a conservative approach. Int J Med Sci 2013; 10: 176-182
Kim YG, Sun BJ, Park GM, Han S, Kim DH, Song JM, Kang DH, Song JK. Aortopathy and bicuspid aortic valve: haemodynamic burden is main contributor to aortic dilatation. Heart 2012; 98: 1822-1827
Bissell MM, Hess AT, Biasiolli L, Glaze SJ, Loudon M, Pitcher A, Davis A,Prendergast B, Markl M, Barker AJ et al. Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type. Circ Cardiovasc Imaging 2013; 6: 499-507
Biner S, Rafique AM, Ray I, Cuk O, Siegel RJ, Tolstrup K. Aortopathy is prevalent in relatives of bicuspid aortic valve patients. J Am Coll Cardiol 2009; 53: 2288-2295
Pepe G, Nistri S, Giusti B, Sticchi E, Attanasio M, Porciani C, Abbate R, Bonow RO, Yacoub M, Gensini GF. Identification of fibrillin 1 gene mutations in patients with bicuspid aortic valve (BAV) without Marfan syndrome. BMC Med Genet 2014; 15: 23
Alegret JM, Vernis JM, Palazón O, Borràs X, Duran I. Factors related to aortic regurgitation in the presence of a dilated aortic root. Am J Cardiol 2005; 95: 417-420
Schiller NB, Shah PM, Crawford M. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358-367
Hoffman JI, Kaplan S. The incidence of congenital h