Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALKl-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:The t (2;5) (p23; q35) translocation associated with CDSO-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFM-ALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. in this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal anti-bodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features.
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Temel Bulgular & Veri:The mean age of the pediatric and adult patients was 10-years and 38-years, respectively.
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Sonuç & Katkı:Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALKl-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.
🔬Tür:Araştırma Makalesi
📍Kapsam:40 specimens
⚙️Değişkenler:Alan Parametreleri
Abstract
The t (2;5) (p23; q35) translocation associated with CDSO-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFM-ALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. in this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal anti-bodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features. The mean age of the pediatric and adult patients was 10-years and 38-years, respectively. ALK1 was positive in 14 cases (35%) representing 83% of pediatric and 26% of adult patients, statistically significantly higher in the pediatric group (p= 0.01). Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALKl-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.
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Bu Makaleye Atıf Yap
NART, D., ÇAĞIRGAN, S., VERAL, A., ÇETİNGÜL, N., SOYDAN, S., ERTAN, Y., HEKİMGİL, M. (2022). Histopathologic and immunophenotypic features of childhood and adult anaplastic large-cell lymphomas. Turkish Journal of Hematology, Cilt: 18 - Sayı: 4, 265–274. https://ajindex.com/articles/607122