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Dergiler / Turkish Journal of Chemistry / 2008 / Cilt: 32 - Sayı: 2

Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones

Nevin ARIKAN
Başaran DÜLGER
Doğan SÜMENGEN
Sayfa
147–155
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was found that all the tested compounds have good antimicrobial activities.

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Amaç & Hipotez:N-Substituted pyridine carboxamide oximes (2) were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides (1) with primary amines.
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Temel Bulgular & Veri:The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted- 1,2,4-oxadiazin-5-ones (3), which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4).
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Sonuç & Katkı:It was found that all the tested compounds have good antimicrobial activities.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

N-Substituted pyridine carboxamide oximes (2) were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides (1) with primary amines. The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted- 1,2,4-oxadiazin-5-ones (3), which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4). The reaction of pyridine carboxamide oximes with $alpha$- aminoacid ester led to the formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate yields. The structures of the prepared compound were evaluated by spectroscopy. Some of the representatives of 3,4-disubstituted-1,2,4-oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones were screened for antibacterial activity using disc diffusion. It was found that all the tested compounds have good antimicrobial activities.

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Bu Makaleye Atıf Yap

ARIKAN, N., DÜLGER, B., SÜMENGEN, D. (2022). Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry, Cilt: 32 - Sayı: 2, 147–155. https://ajindex.com/articles/602147

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Kaynakça (14)

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