Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [$Sn_4(C_4H_9)_8$(OOCC$H_2C_6H_3CI_2$)4O2 ]
Some of the compounds exhibited significant antibacterial and antifungal activity.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:Some bioactive organotin(IV) derivatives of 3,4-dichlorophenylacetic acid (HL) were synthesized by reacting the ligand acid with various di- or tri-organotin compounds (in suitable mole ratios) in the presence of triethylamine.
📊
Temel Bulgular & Veri:The structural investigation was carried out via multinuclear ( $^1H, ^{13}C,$ and $^{119}Sn$) NMR, IR spectroscopy, and X-ray crystallography.
💡
Sonuç & Katkı:Some of the compounds exhibited significant antibacterial and antifungal activity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
Some bioactive organotin(IV) derivatives of 3,4-dichlorophenylacetic acid (HL) were synthesized by reacting the ligand acid with various di- or tri-organotin compounds (in suitable mole ratios) in the presence of triethylamine. The structural investigation was carried out via multinuclear ( $^1H, ^{13}C,$ and $^{119}Sn$) NMR, IR spectroscopy, and X-ray crystallography. The crystal structure of 4 comprises a central $Sn_2O_2$ core with O atoms bonded to 2 dibutylbis(3,4-dichlorophenylacetato)tin(IV) units. All the Sn atoms of 4 are essentially 5-coordinated in distorted trigonal-bipyramidal geometry. Some of the compounds exhibited significant antibacterial and antifungal activity.
🔖
Bu Makaleye Atıf Yap
BADSHAH, A., DIN, I. U., MIRZA, B., RAUF, M. K., AKHTAR, M. Z., SAEED, M. A. (2022). Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [$Sn_4(C_4H_9)_8$(OOCC$H_2C_6H_3CI_2$)4O2 ]. Turkish Journal of Chemistry, Cilt: 34 - Sayı: 1, 109–118. https://ajindex.com/articles/602115
(a) Pellerito, L.; Nagy, L. Coord. Chem. Rev. 2002, 224, 111-150. (b) Evans, C. J. Chemistry of tin, in: P.J. Smith (Ed. $2^{nd}$ ed., Blackie, London, 1998 (Chapter 10). 2. Prabusankar, G.; Murugavel, R. Organomeallics. 2004, 23, 5644-5647. 3. Tiekink, E. R. T. Trends Organomet. Chem. 1994, 1, 71-116. 4. Pellerito, C.; Nagy, L.; Pellerito, L.; Szorcsik, A. J. Organomet. Chem. 2006, 691, 1733-1747. 5. Gielen, M. Appl. Organomet. Chem. 2002, 16, 481-494. 6. Cox, C. J. Pest. Reforms. 1997, 17, 14-20. 7. Otera, J.; Dan-Oh, N.; Nozaki, H. Tetrahedron. 1993, 49, 3065- 3074. 8. Parrin, D. D.; Armarego, W. L. F. Purification of Laboratory Chemicals, 3rd ed., Butterworths, Heinemann, Oxford, 1997. 9. Imtiaz-ud-Din.; Mazhar, M.; Khan, K. M.; Maohon, M. F.; Molloy, K. C. J. Organomet. Chem. 2004, 689, 899-908. 10. Altomare, A.; Burla, M. C.; Camalli, M.; Cascarano, G.; Giacovazzo, C.; Guagliardi, A.; Polidori, G. J. Appl. Cryst. 1994, 27, 435. 11. Rae, A. D, RAELS. A Comprehensive Constrained Least Squares Refinement Program, University of New South Wales, 1996. 12. (a) Farrugia, L. J. J. Appl. Cryst. 1997, 30, 565. (b) Persistence of Vision (POV) Pty. Ltd. Persistence of Vision (TM) Raytracer, Williamstown, Victoria, Australia, 2004. 13. Kazmi, S. U.; Ali, S. N.; Jamal, S. A.; Rahman, A. J. Pharm. Sci. 1991, 4, 113-116. 14. Rahman, A.; Choudhary, M. I.; Thomson, W. J. “Bioassay Techniques for Drug Development”,Harwood Academic Publishers, Amsterdam, 2001. 15. Imtiaz-ud-Din.; Mazhar, M.; Molloy, K.C. Main Group Metal Chem. 2006, 29, 11-19. 16. Danish, M.; Alt, G.H.; Badshah, A.; Ali, S.; Mazhar, M.; Nazar, I. J. Organomet. Chem. 1995, 486, 51-56. 17. Willem, R.; Bouhdid, A.; Biesemans, M.; Martins, J. C.; Vos, D.; Tiekink, E. R. T.; Gielen, M. J. Organomet. Chem. 1996, 514, 203-212. 18. Holecek, J.; Nadvornik, M.; Handlir, K. J. Organomet. Chem. 1983, 241, 177-184. 19. Danish, M.; Ali, S.; Mazhar, M. Badshah, A. Choudhary, M. I.; Alt, H. G.; Kehr, G. Polyhedron. 1995, 14, 3115-3123. 20. Gielen, M.; El-Khloufi, A.; Biesemans, M.; Kayser, F.; Willem, R. Appl. Organomet. Chem. 1993, 7, 201-206. 21. Saeed, M. A.; Craig, D. C.; Badshah, A.; Ali, S.; Rauf, M. K. Acta Cryst. 2005, E61, m2595-m2597. 22. Ng, S. W.; Das, V. G. K. Acta Cryst. 1995, C51, 1774-1776. 23. Parvez, M.; Anwar, S.; Badshah, A.; Ahmad, B.; Majeed, A.; Ashfaq, M. Acta Cryst. 2000, C56, 159-160.