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Dergiler / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 3

Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds

Tuğba GÜNGÖR
Ferah CÖMERT ÖNDER
Yusuf DİLGİN
Mehmet AY
Ozlem SAĞLAM
Sayfa
780–793
Yayın Tarihi
2022-11-04
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This voltammetric procedure indicatesthat nitro-substituted benzamide drugs can be successfully determined in pharmaceutical samples.

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Amaç & Hipotez:Voltammetric behaviors of six nitro-substituted benzamides, which are potential prodrug candidates fornitroreductase-based cancer therapy, were investigated using cyclic voltammetry (CV) and differential pulse voltammetry(DPV).
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Temel Bulgular & Veri:The electrochemical behavior of aromatic nitro (ArNO 2) compounds by CV indicates that compounds involvevarious reduction/oxidation steps including the formation of aromatic nitro radical, nitroso, hydroxylamine, and aminegroups.
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Sonuç & Katkı:This voltammetric procedure indicatesthat nitro-substituted benzamide drugs can be successfully determined in pharmaceutical samples.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Voltammetric behaviors of six nitro-substituted benzamides, which are potential prodrug candidates fornitroreductase-based cancer therapy, were investigated using cyclic voltammetry (CV) and differential pulse voltammetry(DPV). The electrochemical behavior of aromatic nitro (ArNO 2) compounds by CV indicates that compounds involvevarious reduction/oxidation steps including the formation of aromatic nitro radical, nitroso, hydroxylamine, and aminegroups. Applicability of the voltammetric determination of these prodrug candidates was studied by recording theirDPVs, carried out in mixed media (Britton Robinson buffer solution + DMF) at various pH values on a pencil graphiteelectrode (PGE). Results show that the PGE can offer a disposable, low-cost, and sensitive electrochemical determinationmethod for identifying nitro benzamide compounds. Under the experimental conditions, the PGE had a linear responserange from 0.5 to 100 µ M 4-nitro- N -(2-nitrophenyl)benzamide (compound 2). This voltammetric procedure indicatesthat nitro-substituted benzamide drugs can be successfully determined in pharmaceutical samples.

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Bu Makaleye Atıf Yap

GÜNGÖR, T., ÖNDER, F. C., DİLGİN, Y., AY, M., SAĞLAM, O. (2022). Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 3, 780–793. https://ajindex.com/articles/601954

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