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Dergiler / Turkish Journal of Chemistry / 2017 / Cilt: 41 - Sayı: 1

Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-a]quinazolinones

Negar MOHAMMADHOSSEINI
Mina SAEEDI
Shahram MORADI
Mohammad MAHDAVI
Omidreza FIRUZI
Abbas SHAFIEE
Alireza FOROUMADI
Sayfa
125–134
Yayın Tarihi
2022-11-05
DOI
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The latter compound reacted with various 2-chloro-N -substituted acetamides to afford the corresponding fused quinazolinone derivatives.

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Amaç & Hipotez:Various thioxo-quinazolino[3,4-a]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines.
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Temel Bulgular & Veri:Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS 2 gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H -quinazolino[3,4-a]quinazolin- 13-one.
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Sonuç & Katkı:The latter compound reacted with various 2-chloro-N -substituted acetamides to afford the corresponding fused quinazolinone derivatives.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Various thioxo-quinazolino[3,4-a]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines. Synthesis of the target compounds was started from isatoic anhydride. Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS 2 gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H -quinazolino[3,4-a]quinazolin- 13-one. The latter compound reacted with various 2-chloro-N -substituted acetamides to afford the corresponding fused quinazolinone derivatives.

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Bu Makaleye Atıf Yap

MOHAMMADHOSSEINI, N., SAEEDI, M., MORADI, S., MAHDAVI, M., FIRUZI, O., SHAFIEE, A., FOROUMADI, A. (2022). Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-a]quinazolinones. Turkish Journal of Chemistry, Cilt: 41 - Sayı: 1, 125–134. https://ajindex.com/articles/601865

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