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Dergiler / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 2

Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides

Hira KHALID
Muhammad Arif LODHI
Almas SATTAR
Aziz UR REHMAN
Muhammad Athar ABBASI
Sabahat Zahra SIDDIQUI
Shahid RASOOL
Farman Ali KHAN
Sayfa
401–417
Yayın Tarihi
2022-11-05
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a–6k, bearing multifunctional moieties.
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Temel Bulgular & Veri:The target acetamides were derived from 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H -1,2,4-triazole-3-thiol (3).
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Sonuç & Katkı:The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a–6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H -1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.

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Bu Makaleye Atıf Yap

KHALID, H., LODHI, M. A., SATTAR, A., REHMAN, A. U., ABBASI, M. A., SIDDIQUI, S. Z., RASOOL, S., KHAN, F. A. (2022). Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 2, 401–417. https://ajindex.com/articles/601759

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