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Dergiler / Turkish Journal of Chemistry / 2019 / Cilt: 43 - Sayı: 1

The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

İsmet YILMAZ
Nuran ERCAL
Nigar VARDI
Merve Gökşin KARAASLAN
Burhan ATEŞ
Hakan PARLAKPINAR
Sayfa
39–49
Yayın Tarihi
2022-11-04
DOI
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According to biochemicaldata, malondialdehyde levels exhibited a significant increase (P

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Amaç & Hipotez:N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties.The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrainsof rats by using motor coordination tests and biochemical and histological analysis.
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Temel Bulgular & Veri:Thirty adult Wistar albino rats weredivided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg)+ NACA (100 mg/kg) (n = 10).
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Sonuç & Katkı:According to biochemicaldata, malondialdehyde levels exhibited a significant increase (P
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties.The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrainsof rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats weredivided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg)+ NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection. Performancewas measured for a period of 28 days. The rotarod and accelerod tests were performed prior to and after the experimentalperiod. After the experimental period, rats were sacrificed and midbrain tissues were removed. According to biochemicaldata, malondialdehyde levels exhibited a significant increase (P

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Bu Makaleye Atıf Yap

YILMAZ, İ., ERCAL, N., VARDI, N., KARAASLAN, M. G., ATEŞ, B., PARLAKPINAR, H. (2022). The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity. Turkish Journal of Chemistry, Cilt: 43 - Sayı: 1, 39–49. https://ajindex.com/articles/601647

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