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Dergiler / Turkish Journal of Chemistry / 2022 / Cilt: 46 - Sayı: 3

Synthesis of some new isoxazole compounds and their biological tyrosinase and antioxidant activities

Seda FANDAKLI
Sayfa
747–753
Yayın Tarihi
2022-11-04
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a result, the change of functional groups in the synthesized compounds caused a significant difference in the biological properties of 8-14.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, 7 new isoxazole compounds (8-14) were synthesized from the cyclization of chalcone compounds (1-7) containing different functional groups with hydroxylamine hydrochloride in alkaline medium.
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Temel Bulgular & Veri:Tyrosinase and antioxidant properties of 8-14 were investigated. $IC_{50}$ values for the tyrosinase enzyme inhibition of compounds 8, 11, 12, and 13 were varied between 61.47 ± 3.46 and 188.52 ± 5.85, while compounds 9, 10 and 14 did not show any inhibition effect.
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Sonuç & Katkı:As a result, the change of functional groups in the synthesized compounds caused a significant difference in the biological properties of 8-14.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In this study, 7 new isoxazole compounds (8-14) were synthesized from the cyclization of chalcone compounds (1-7) containing different functional groups with hydroxylamine hydrochloride in alkaline medium. Tyrosinase and antioxidant properties of 8-14 were investigated. $IC_{50}$ values for the tyrosinase enzyme inhibition of compounds 8, 11, 12, and 13 were varied between 61.47 ± 3.46 and 188.52 ± 5.85, while compounds 9, 10 and 14 did not show any inhibition effect. The antioxidant properties of 8-14 were investigated by DPPH and CUPRAC methods. Compound 12 showed the best DPPH radical scavenging activity (SC50: 40.21 ± 2.71), while 12 and 13 had shown the greatest Cupric ion reducing effect as 1.233 ± 0.015 and 1.245 ± 0.019 mg TEAC/mg, respectively. As a result, the change of functional groups in the synthesized compounds caused a significant difference in the biological properties of 8-14.

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Bu Makaleye Atıf Yap

FANDAKLI, S. (2022). Synthesis of some new isoxazole compounds and their biological tyrosinase and antioxidant activities. Turkish Journal of Chemistry, Cilt: 46 - Sayı: 3, 747–753. https://ajindex.com/articles/601386

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Kaynakça (11)

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