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Dergiler / Turkish Journal of Biology / 2016 / Cilt: 40 - Sayı: 2

Collagen/PEO/gold nanofibrous matrices for skin tissue engineering

Ömer AKTÜRK
Dilek KESKİN
Sayfa
380–398
Yayın Tarihi
2022-10-17
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:As a novel approach in skin tissue engineering, gold nanoparticles (AuNPs) were synthesized and incorporated at different concentrations into collagen/PEO nanofibrous matrices in this study.
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Temel Bulgular & Veri:The group containing 14.27 ppm AuNPs (CM-Au) had the best nanofibrous morphology.
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Sonuç & Katkı:As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

As a novel approach in skin tissue engineering, gold nanoparticles (AuNPs) were synthesized and incorporated at different concentrations into collagen/PEO nanofibrous matrices in this study. The group containing 14.27 ppm AuNPs (CM-Au) had the best nanofibrous morphology. CM-Au was cross-linked with glutaraldehyde vapor (CM-AuX). All groups were disrupted in collagenase in 2 h, but cross-linked groups and Matriderm1397904493 resisted hydrolytic degradation for 7 and 14 days, respectively. Due to its small pores and dense structure, lower water swelling results (7.26 ± 2.62 g/g) were obtained for CM-AuX than Matriderm (17.51 ± 1.97 g/g). CM-Au and Matriderm had statistically similar tensile strength and elastic modulus, but elongation at break of CM-Au (over 100%) was significantly better than that of Matriderm. After cross-linking, tensile strength and elastic modulus of collagen matrix was further improved. AuNPs (37 and 42 nm) seemed to be nontoxic on 3T3 fibroblasts and keratinocytes for different time periods. CM-AuX scaffold extracts were also nontoxic for 3T3 fibroblasts and keratinocytes. The L929 cell attachment and proliferation on CM-AuX were comparable with Matriderm, indicating good in vitro biocompatibility. As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.

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Bu Makaleye Atıf Yap

AKTÜRK, Ö., KESKİN, D. (2022). Collagen/PEO/gold nanofibrous matrices for skin tissue engineering. Turkish Journal of Biology, Cilt: 40 - Sayı: 2, 380–398. https://ajindex.com/articles/600438

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