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Dergiler / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 4

The effect of TWIST silencing in metastatic chordoma cells

Ömer Faruk BAYRAK
Esra AYDEMİR
Fikrettin ŞAHİN
Ezgi KAŞIKCI
Burcu COŞKUNÇELEBİ
Sayfa
279–285
Yayın Tarihi
2022-10-17
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This study indicates that Twist might have a role in metastatic chordoma cells.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Chordoma is a slowly growing and invasive bone tumor with a tendency to metastasize locally in advanced stages.
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Temel Bulgular & Veri:The TWIST gene was silenced by short hairpins in chordoma cell line MUG-Chor1 and effects on metastasiswere investigated by wound healing/gap closure and invasion assays.
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Sonuç & Katkı:This study indicates that Twist might have a role in metastatic chordoma cells.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Chordoma is a slowly growing and invasive bone tumor with a tendency to metastasize locally in advanced stages. It isessential to discover new therapeutics that target genes involved in the metastasis of chordoma. Epithelial-mesenchymal transition(EMT) might robustly influence the metastasis of a tumor bulk. To our knowledge, this is the first time to show that EMT might havea role in chordoma metastasis. In this study, we aim to investigate the possible role of Twist, a key player transcription factor of EMT,in chordoma metastasis. The TWIST gene was silenced by short hairpins in chordoma cell line MUG-Chor1 and effects on metastasiswere investigated by wound healing/gap closure and invasion assays. Twist-silenced MUG-Chor1 cells were found to be less migratoryand less invasive when compared to the negative control. This study indicates that Twist might have a role in metastatic chordoma cells.

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Bu Makaleye Atıf Yap

BAYRAK, Ö. F., AYDEMİR, E., ŞAHİN, F., KAŞIKCI, E., COŞKUNÇELEBİ, B. (2022). The effect of TWIST silencing in metastatic chordoma cells. Turkish Journal of Biology, Cilt: 42 - Sayı: 4, 279–285. https://ajindex.com/articles/600270

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Kaynakça (14)

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