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Dergiler / The Turkish Journal of Ear Nose and Throat / 2020 / Cilt: 30 - Sayı: 2

The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model

Hakan AVCI
Burak DİKMEN
Şaban ÇELEBİ
Sayfa
46–51
Yayın Tarihi
2022-10-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz.Conclusion: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.

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Amaç & Hipotez:Objectives: This study aims to investigate the protective effect of hyperbaric oxygen therapy (HBOT) as an antioxidant agent on cisplatin ototoxicity.Materials and Methods: Between June 4th, 2014 and June 13th, 2014, a total of 15 adult female Wistar albino rats were used in this study.
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Temel Bulgular & Veri:Group B comprised of five rats receiving three cycles of HBOT after 10 mg/kg of IP cisplatin administration.
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Sonuç & Katkı:In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz.Conclusion: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:2014 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: This study aims to investigate the protective effect of hyperbaric oxygen therapy (HBOT) as an antioxidant agent on cisplatin ototoxicity.Materials and Methods: Between June 4th, 2014 and June 13th, 2014, a total of 15 adult female Wistar albino rats were used in this study. The rats were divided into the following groups: Group A comprised of five rats and had prophylactic one course of HBOT before intraperitoneal (IP) cisplatin injection, followed by two more courses of HBOT. Group B comprised of five rats receiving three cycles of HBOT after 10 mg/kg of IP cisplatin administration. Group C served as the control group, including five rats, and received 10 mg/kg IP cisplatin without any additional treatment. The distortion product otoacoustic emission amplitudes of the rats were obtained before and after the study.Results: Group A and Group C showed a significant decrease in all measurements (4,004 Hz, 4,761 Hz, 5,188 Hz, 5,652 Hz, 6,726 Hz, and 7,996 Hz) after cisplatin administration compared to that of baseline measurement. In Group B, a significant decrease was observed in the majority of the measurements, although no significant difference was found in 4,761 Hz.Conclusion: Our study results suggest that HBOT neither provides a protective nor therapeutic effect in a rat cisplatin-ototoxicity model.

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Bu Makaleye Atıf Yap

AVCI, H., DİKMEN, B., ÇELEBİ, Ş. (2022). The effects of hyperbaric oxygen therapy on an experimental cisplatin-induced ototoxicity model. The Turkish Journal of Ear Nose and Throat, Cilt: 30 - Sayı: 2, 46–51. https://ajindex.com/articles/597898

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Kaynakça (16)

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