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Dergiler / The European Research Journal / 2020 / Cilt: 6 - Sayı: 3

The effects of fulvestrant treatment on hormone receptor-positive metastatic breast cancer

Orçun Can
Abdullah Sakin
Serdar Arıcı
Şaban Seçmeler
Nurgül Yaşar
Çağlayan Geredeli
Şener Cihan
Sayfa
210–215
Yayın Tarihi
2022-10-18
DOI
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The 12-month OS rate was calculated as 82.4%, and the 36-month OS rate was 50%.Conclusions: Fulvestrant contributes both PFS and OS in patients with hormone receptor-positive metastaticbreast cancer and this effect is more clear in using fulvestrant as first-line treatment.

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Amaç & Hipotez:Objectives: To determine fulvestrant efficacy and tolerability in Turkish patients with hormone receptor-positive metastatic breast cancer.Methods: Patients who developed metastasis while taking tamoxifen or aromatase inhibitors in the adjuvantperiod or metastatic disease at the diagnosis.
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Temel Bulgular & Veri:Fulvestrant 500 mg was administered intramuscularly every 28days.
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Sonuç & Katkı:The 12-month OS rate was calculated as 82.4%, and the 36-month OS rate was 50%.Conclusions: Fulvestrant contributes both PFS and OS in patients with hormone receptor-positive metastaticbreast cancer and this effect is more clear in using fulvestrant as first-line treatment.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: To determine fulvestrant efficacy and tolerability in Turkish patients with hormone receptor-positive metastatic breast cancer.Methods: Patients who developed metastasis while taking tamoxifen or aromatase inhibitors in the adjuvantperiod or metastatic disease at the diagnosis. Fulvestrant 500 mg was administered intramuscularly every 28days. Progression-free survival (PFS) and overall survival (OS) durations were calculated.Results: In this particular research, totally 137 patients were participated. Median PFS was 9 months (95%CI, 5.7-10.3). The 12-month PFS rate was calculated as 42%, and the 36-month PFS rate was 17%. The medianPFS was not reached in the first line use of fulvestrant in the metastatic period but 9 months and 7 months inthe second and subsequent lines respectively. Results indicated that this difference was statistically significant(p = 0.002). It was shown that patients with liver and brain metastasis had lower PFS compared patients withno liver and no brain metastasis. The estimated median OS was 38 months after fulvestrant started. The 12-month OS rate was calculated as 82.4%, and the 36-month OS rate was 50%.Conclusions: Fulvestrant contributes both PFS and OS in patients with hormone receptor-positive metastaticbreast cancer and this effect is more clear in using fulvestrant as first-line treatment.

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Bu Makaleye Atıf Yap

Can, O., Sakin, A., Arıcı, S., Seçmeler, Ş., Yaşar, N., Geredeli, Ç., Cihan, Ş. (2022). The effects of fulvestrant treatment on hormone receptor-positive metastatic breast cancer. The European Research Journal, Cilt: 6 - Sayı: 3, 210–215. https://ajindex.com/articles/597685

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Kaynakça (9)

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