Dergiler / The European Research Journal / 2020 / Cilt: 6 - Sayı: 6

A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children

Sayfa
600–608
Yayın Tarihi
2022-10-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Hemogram, liver functiontests, cytokine levels, lymphocyte sub-group distribution, immunoglobulin levels and total antioxidant capacitymeasurements were not different.Conclusions: Three lipid emulsions which are used for parenteral nutrition treatment in intensive care unitpatients are clinically and biochemically useful.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: Lipid emulsions are not only considered as a source of energy, but also as a regulatory substancefor key metabolic functions in different diseases.
📊
Temel Bulgular & Veri:The aim of the present study was to compare clinical,biochemical and immunological effects of olive oil, soybean oil and omega-3 fatty acid which are administratedto the children in parenteral nutrition products.Methods: Patients who were admitted to pediatric intensive care unit and had parenteral nutrition for 7 daysare included in the study.
💡
Sonuç & Katkı:Hemogram, liver functiontests, cytokine levels, lymphocyte sub-group distribution, immunoglobulin levels and total antioxidant capacitymeasurements were not different.Conclusions: Three lipid emulsions which are used for parenteral nutrition treatment in intensive care unitpatients are clinically and biochemically useful.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: Lipid emulsions are not only considered as a source of energy, but also as a regulatory substancefor key metabolic functions in different diseases. The aim of the present study was to compare clinical,biochemical and immunological effects of olive oil, soybean oil and omega-3 fatty acid which are administratedto the children in parenteral nutrition products.Methods: Patients who were admitted to pediatric intensive care unit and had parenteral nutrition for 7 daysare included in the study. The patients were randomised into 3 groups based on the admission order, including10 patients in each group. The children in Group O were fed by a lipid emulsion based on olive oil; the childrenin Group S were fed by a soybean based lipid emulsion and the children in group F were fed by soybean basedlipid emulsion with omega-3 based solution. Analysis were made on the first and the seventh day. Laboratoryparameters as well as hemogram, biochemical analysis, immunoglobulins, lymphocyte subgroup panel andcytokine levels were evaluated just before parenteral nutrition (day 0, basal value) and at day 7 of parenteralnutrition. Clinical monitoring parameters included body weight, and circumference of the mid-upper arm.Results: Thirty children were enrolled into the study. Total cholesterol and triglyceride levels significantlyincreased in Group O whereas triglyceride level significantly increased in Group S. Hemogram, liver functiontests, cytokine levels, lymphocyte sub-group distribution, immunoglobulin levels and total antioxidant capacitymeasurements were not different.Conclusions: Three lipid emulsions which are used for parenteral nutrition treatment in intensive care unitpatients are clinically and biochemically useful.

🔖

Bu Makaleye Atıf Yap

Çakır, S. Ç., Özkan, T. M. B., Özgür, T. (2022). A comparison of clinical, hepatic and immunological effects of three different parenteral lipid emulsions in children. The European Research Journal, Cilt: 6 - Sayı: 6, 600–608. https://ajindex.com/articles/597485

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Hojsak I, Colomb V, Braegger C, Bronsky J, Campoy C, Domellöf M, et al. ESPGHAN committee on nutrition position paper. Intravenous lipid emulsions and risk of hepatotoxicity in infants and children: a systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 2016;62:776-92
  2. Waitzberg DL, Torrinhas RS, Jacintho TM. New parenteral lipid emulsions for clinical use. J Parenter Enter Nutr 2006;30:351-67
  3. Mayer K, Gokorsch S, Fegbeutel C, Hattar K, Rosseau S, Walmrath D, et al.Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003;167:1321-8
  4. Wanten GJA. Parenteral lipid tolerance and adverse effects: fat chance for trouble? JPEN J Parenter Enteral Nutr 2015;39:33-8
  5. Mehta NM, Compher C. A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. JPEN J Parenter Enteral Nutr 2009;33:260-76
  6. Beaufrere B. Eflicacite nutritionnelle et metabolique de Cli nOleic 20%. Nutr Clin Metabol 1996;10:29-31
  7. Goulet O, de Potter S, Antebi H, Driss F, Colomb V, Bereziat G, et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 1999;70:338-45
  8. Shulman RJ, Phillips S. Parenteral nutrition in infants and children. J Pediatr Gastroenterol Nutr 2003;36:587-607
  9. Oshita M, Takehara H, Yamaguchi M, Doi K, Ueda N, Naito S, et al.Significance of administration of fat emulsion: hepatic changes in infant rats receiving total parenteral nutrition with and without fat. Clin Nutr 2004;23:1060-8
  10. Dahlström KA, Goulet OJ, Roberts RL, Ricour C, Ament ME. Lipid tolerance in children receiving long-term parenteral nutrition: a biochemical and immunologic study. J Pediatr 1988;113:985-90
  11. Ythier-Moury P, Dutot G, Melin C. Modifications of biliary secretion associated with parenteral nutrition in the rat: influence of fat emulsion composition. Clin Nutr 1990;9:26
  12. Calder PC. Lipids and the critically ill patient. Nestle Nutr Workshop Ser Clin Perform Programme 2003;8:75-91
  13. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJA. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intens Care Med 2010;36:735-49
  14. Goren A, Stankiewicz H, Goldstein R, Drukker A. Fish oil treatment of hyperlipidemia in children and adolescents receiving renal replacement therapy. Pediatrics 1991;88:265-8
  15. Calkins KL, Dunn JC