Dergiler / Retina-Vitreus / 2022 / Cilt: 31 - Sayı: 3

Evaluation of Structural Changes of Choroid in Intermediate Age-Related Macular Degeneration

Sayfa
215–219
Yayın Tarihi
2022-10-17
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

No correlation was found to support the hypothesis that inner retinal thinning develops due to choroidal and/or outer retinal changes.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Purpose: To evaluate the structural changes in the choroid by binarization method in intermediate age-related macular degeneration (AMD) and to examine the correlation between parafoveal external retinal and internal retinal thinning.
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Temel Bulgular & Veri:Material method: Enhanced depth imaging optical coherence tomography images of 50 patients diagnosed with intermediary AMD and age matched 30 healthy subjects were analyzed retrospectively.
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Sonuç & Katkı:No correlation was found to support the hypothesis that inner retinal thinning develops due to choroidal and/or outer retinal changes.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Purpose: To evaluate the structural changes in the choroid by binarization method in intermediate age-related macular degeneration (AMD) and to examine the correlation between parafoveal external retinal and internal retinal thinning. Material method: Enhanced depth imaging optical coherence tomography images of 50 patients diagnosed with intermediary AMD and age matched 30 healthy subjects were analyzed retrospectively. Results: Compared to the control group in the AMD group; the central choroidal thickness, choroidal area, stroma area and lumen area were found to be significantly reduced. There was no significant difference in the choroidal vascular index (CVI) compared to the control group in intermediate AMD. In the AMD group, significant thinning was found in the parafoveal inner and outer retinal thickness compared to the control group. When the correlation between parafoveal inner and outer retinal thicknesses and choroidal parameters were evaluated individually in the AMD group, no significant correlation was found. Discussion: In non-neovascular intermediate AMD cases, there was a decrease in inner and outer retinal thicknesses, central choroidal thickness, lumen and stroma area of the choroid, however, the decrease in CVI was not prominent. No correlation was found to support the hypothesis that inner retinal thinning develops due to choroidal and/or outer retinal changes.

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Bu Makaleye Atıf Yap

ÖZCAN, G., YANIK, Ö., DEMİREL, S., BATIOĞLU, F., ÖZMERT, E. (2022). Evaluation of Structural Changes of Choroid in Intermediate Age-Related Macular Degeneration. Retina-Vitreus, Cilt: 31 - Sayı: 3, 215–219. https://ajindex.com/articles/589000

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Kaynakça (15)

  1. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no
  2. Arch Ophthalmol (Chicago, Ill 1960). 2001;119:1417-36
  3. Ferris FL 3rd, Wilkinson CP, Bird A, et al. Clinical classification of age-related macular degeneration. Ophthalmology. 2013;120:844-51
  4. Seddon JM, McLeod DS, Bhutto IA, et al. Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration. JAMA Ophthalmol. 2016;134(11):1272-80
  5. Berenberg TL, Metelitsina TI, Madow B, et al. The association between drusen extent and foveolar choroidal blood flow in age- related macular degeneration. Retina. 2012;32:25-31
  6. Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci. 2000;41:3117-23
  7. The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no
  8. Control Clin Trials. 1999;20:573-600
  9. Huang Y, Gangaputra S, Lee KE, et al. Signal Quality Assessment of Retinal Optical Coherence Tomography Images. Invest Ophthalmol Vis Sci. 2012;1000:2133-41
  10. Sonoda S, Sakamoto T, Yamashita T. Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images. Invest Ophthalmol Vis Sci. 2014;55:3893-9
  11. Zheng F, Gregori G, Schaal KB, et al. Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging. Invest Ophthalmol Vis Sci. 2016;57:6256- 64
  12. Ferrara D, Silver RE, Louzada RN, et al. Optical Coherence Tomography Features Preceding the Onset of Advanced Age- Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:3519-29
  13. Yiu G, Chiu SJ, Petrou PA, et al. Relationship of central choroidal thickness with age-related macular degeneration status. Am J Ophthalmol. 2015;159:617-26
  14. Razavi S, Souied EH, Darvizeh F, et al. Assessment of Choroidal Topographic Changes by Swept-Source Optical Coherence Tomography After Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration. Am J Ophthalmol. 2015;160:1006-13
  15. Agrawal R, Salman M, Tan K-A, et al. Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? PLoS One. 2016;11:e0146344