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Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Secondary Metabolites with Tyrosinase and Acetylcholinesterase Inhibitory Activities from Leonuri Fructus

Penghua SHU
Yingying FEİ
Mengzhu YU
Yamin LI
Yuehui LUO
Fugang XIAO
Huiqing ZHU
Jihong HUANG
Ting XU
Yueyue LOU
Sayfa
417–425
Yayın Tarihi
2022-10-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Compounds 3, 5–6 and 9–10 exhibited significant inhibitory activities against acetylcholinesterase, similar to the positive control, galantamine.

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Amaç & Hipotez:Fourteen secondary metabolites, including one cinnamate derivative (1), three spirocyclic nortriterpenoids (2–4), three phenylethanoid glycosides (5–7), four lignans (8–11) and three phenolic compounds (12–14) were isolated from the EtOH extract of Leonuri Fructus.
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Temel Bulgular & Veri:Their structures were elucidated on the basis of 1D NMR, 2D NMR and HR-ESI-MS data analysis.
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Sonuç & Katkı:Compounds 3, 5–6 and 9–10 exhibited significant inhibitory activities against acetylcholinesterase, similar to the positive control, galantamine.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Fourteen secondary metabolites, including one cinnamate derivative (1), three spirocyclic nortriterpenoids (2–4), three phenylethanoid glycosides (5–7), four lignans (8–11) and three phenolic compounds (12–14) were isolated from the EtOH extract of Leonuri Fructus. Their structures were elucidated on the basis of 1D NMR, 2D NMR and HR-ESI-MS data analysis. All isolates were tested for their antioxidant, tyrosinase and acetylcholinesterase inhibitory activities. Most of them showed moderate antioxidant activities. Compounds 2–4 exhibited obvious inhibitory activities against mushroom tyrosinase at 25 μM, with %inhibition values of 49.36 ±2.69%, 43.43 ± 3.35%, 51.69 ± 2.81%, respectively, with arbutin used as the positive control (51.90 ± 2.57%). Compounds 3, 5–6 and 9–10 exhibited significant inhibitory activities against acetylcholinesterase, similar to the positive control, galantamine.

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Bu Makaleye Atıf Yap

SHU, P., FEİ, Y., YU, M., LI, Y., LUO, Y., XIAO, F., ZHU, H., HUANG, J., XU, T., LOU, Y. (2022). Secondary Metabolites with Tyrosinase and Acetylcholinesterase Inhibitory Activities from Leonuri Fructus. Records of Natural Products, Cilt: 16 - Sayı: 5, 417–425. https://ajindex.com/articles/588771

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Kaynakça (12)

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