In addition, the cytotoxic activities and antibacterial activities of compounds 1-8 were evaluated, and compounds 6 and 7 exhibited moderate cytotoxic activities against SMMC7721 cell line with IC50 values of 25.9 and 45.8 μM respectively.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:A new benzophenone derivative, shiraone A (1), along with seven known compounds, linchenxantone (2), 4-hydroxymellein (3), hypocrellin A (4), hypocrellin B (5), 9,11-dehydroergosterol peroxide (6), ergosteroal peroxide (7), and lactariolide I (8), were isolated from the cultures of Shiraia sp.
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Temel Bulgular & Veri:BYJB-1, a fungus from the leaves of the medicinal plant Selaginella delicatula.
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Sonuç & Katkı:In addition, the cytotoxic activities and antibacterial activities of compounds 1-8 were evaluated, and compounds 6 and 7 exhibited moderate cytotoxic activities against SMMC7721 cell line with IC50 values of 25.9 and 45.8 μM respectively.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
A new benzophenone derivative, shiraone A (1), along with seven known compounds, linchenxantone (2), 4-hydroxymellein (3), hypocrellin A (4), hypocrellin B (5), 9,11-dehydroergosterol peroxide (6), ergosteroal peroxide (7), and lactariolide I (8), were isolated from the cultures of Shiraia sp. BYJB-1, a fungus from the leaves of the medicinal plant Selaginella delicatula. The structures of these compounds were established via extensive spectroscopic techniques, including 1D/2D NMR, HRESIMS and through comparison with data reported in the literatures. In addition, the cytotoxic activities and antibacterial activities of compounds 1-8 were evaluated, and compounds 6 and 7 exhibited moderate cytotoxic activities against SMMC7721 cell line with IC50 values of 25.9 and 45.8 μM respectively.
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Bu Makaleye Atıf Yap
ZHANG, S., KUANG, M., PENG, W., TAN, J., WANG, W., KANG, F., ZOU, Z., XU, K., CHEN, D. (2022). A New Benzophenone Derivative from the Endophyte Shiraia sp. BYJB-1. Records of Natural Products, Cilt: 16 - Sayı: 5, 471–476. https://ajindex.com/articles/588758
P. Sharma and S.P. Singh (2021). Role of the endogenous fungal metabolites in the plant growth improvement and stress tolerance, in: Fungi Bio-Prospects in Sustainable Agriculture, Environment and Nano-Technology, Ed. V. K. Sharma, M. P. Shah, A. Kumar, 3, 381-401
G.A. Strobel (2003). Endophytes as sources of bioactive products, Microbes. Infect. 5(6), 535-544
S. Kusari, S.P. Pandey and M. Spiteller (2013). Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites, Phytochemistry 91, 81-87
Chinese Pharmacopoeia (2020).Chinese Pharmacopoeia Commission. China Medical Science Press: Beijing, China. 1, 237
K.P. Xu, H. Zou, G.R. Liu, H.P. Long, J. Li, F.S. Li, Z.X. Zou, J.W. Kuangs, X. Xie and G.S. Tan (2011). Selaginellin M, a new selaginellin derivative from Selaginella pulvinata, J. Asian Nat. Prod. Res. 13(11), 1051-1055
T. Kishi, S. Tahara, N. Taniguchi, M. Tsuda and S. Takahashi (1991). New Perylenequinones from Shiraia bambusicola, Planta Med. 57(4), 376-379
X.M. Jia, X.H. Xu, B.C. Zhuang and H.P. Lin (2006). The progress of biological research of medicinal fungus Shiraia bambusicola, Microbiology 33(3), 147-150
Y.L. Li, Y. Xu, Q.M. Liao, M.M. Xie, H. Tao and H.L. Wang (2021). Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of Staphylococcus aureus, Microb. Biotechnol. 14(2), 692-707
T. Wang, Z. Dong, D.J. Zhou, K.L. Sun, Y.Q. Zhao, B. Wang and Y. Chen (2020). Structure and immunostimulating activity of a galactofuranose-rich polysaccharide from the bamboo parasite medicinal fungus Shiraia bambusicola, J. Ethnopharmacol. 257, 112833
Y. Zhang, Y. Luo, X.F. Tian and Z.Q. Wu (2020). Improvement on the antioxidant activity of polysaccharides by submerged fermentation of Shiraia bambusicola GDMCC 60438 (Ascomycota), Int. J. Med. Mushrooms 22(6), 605-614
A.J. Drummond and R.D. Waigh (2000). The development of microbiological methods for phytochemical screening, Recent. Res. Devel. Phytochem. 4,143-152 [12] P.C. Lim, H. Ramli, N.K. Kassim, Z. Ali, I.A. Khan, K. Shaari and A. Ismail (2019). Chemical constituents from the stem bark of Clausena excavata Burm. f, Biochem. Syst. Ecol. 82, 52-55
Q. Zeng, J. Ye, J. Ren, X.R. Cheng, J.J. Qin, H.Z. Jin and W.D. Zhang (2013). Chemical constituents from Aphanamixis grandifolia, Chem. Nat. Compd. 49(3), 486-492