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Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Bronchodilator Phenylpropanoid Glycosides from the Seeds of Prunus mahaleb L.

Maged S. Abdel-KADER
Mubarak A. ALMATRİ
Mohammed A. ALGHAFİS
Najeeb Ur REHMAN
Sayfa
443–453
Yayın Tarihi
2022-10-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The bronchodilator effect proved to be mediated via dual anticholinergic and Ca2+ channels blocking effects.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Prunus mahaleb seeds were selected for phytochemical study directed by ex-vivo bronchodilator effect based on the traditional use for the treatment of respiratory problems.
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Temel Bulgular & Veri:From the active chloroform fraction, five known phenylpropanoid glycosides: cis-melilotoside sodium salt (1), cis-methoxy-melilotoside (2), 3-(2-O- -D-glucopyranosyl-4-methoxyphenyl) propanoic acid (3), trans-methoxy-melilotoside (4) and transmelilotoside (5) were identified for the first time from genus Prunus.
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Sonuç & Katkı:The bronchodilator effect proved to be mediated via dual anticholinergic and Ca2+ channels blocking effects.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Prunus mahaleb seeds were selected for phytochemical study directed by ex-vivo bronchodilator effect based on the traditional use for the treatment of respiratory problems. From the active chloroform fraction, five known phenylpropanoid glycosides: cis-melilotoside sodium salt (1), cis-methoxy-melilotoside (2), 3-(2-O- -D-glucopyranosyl-4-methoxyphenyl) propanoic acid (3), trans-methoxy-melilotoside (4) and transmelilotoside (5) were identified for the first time from genus Prunus. Chemical structure of the compounds elucidated by spectroscopic techniques such as 1D, 2D NMR and HRESI/ MS. Compounds 1, 2, 4, 5 showed promising bronchodilator effects against carbamylcholine (CCh) induced bronchospasm in isolated Guinea-pig trachea while 3 was found completely inactive. The mechanism(s) of action was studied using both CCh, low K+ (25 mM) and high K+ (80 mM)-mediated contractions and compound 2 was found distinctly more potent and efficacious against CCh compared to both types of K+- mediated contractions where partial efficacy was observed, hence showed dual inhibition of cholinergic receptors followed by Ca2+ channels. The anticholinergic and Ca2+ inhibitory activities of compound 2 were further confirmed when it deflected CCh concentration response curves (CRCs) without suppression, whereas its higher doses shifted Ca2+ CRCs similar to verapamil. The bronchodilator effect proved to be mediated via dual anticholinergic and Ca2+ channels blocking effects.

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Bu Makaleye Atıf Yap

Abdel-KADER, M. S., ALMATRİ, M. A., ALGHAFİS, M. A., REHMAN, N. U. (2022). Bronchodilator Phenylpropanoid Glycosides from the Seeds of Prunus mahaleb L.. Records of Natural Products, Cilt: 16 - Sayı: 5, 443–453. https://ajindex.com/articles/588753

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