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Dergiler / Journal of the Turkish-German Gynecological Association / 2012 / Cilt: 13 - Sayı: 2

Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome

Polikistik over sendromlu hastalarda total ve lipid bağlı sialik asit seviyeleri

Osman ÇAĞLAYAN
Nevin SAĞSÖZ
Aykan YÜCEL
Volkan NOYAN
Ali ÖZCAN
Sayfa
79–84
Yayın Tarihi
2022-10-18
DOI
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Bulgular: Serum TSA seviyeleri açısından gruplar arasında anlamlı fark yoktu.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Polikistik over sendromlu hastalarda (PKOS) serum total ve lipid bağlı sialik asit (TSA&LBSA) düzeylerinin değerlendirilmesi.
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Temel Bulgular & Veri:Gereç ve Yöntemler: Çalışmaya kırk PKOSlu hasta ve 35 sağlıklı kontrol dahil edildi.
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Sonuç & Katkı:Bulgular: Serum TSA seviyeleri açısından gruplar arasında anlamlı fark yoktu.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Amaç: Polikistik over sendromlu hastalarda (PKOS) serum total ve lipid bağlı sialik asit (TSA&LBSA) düzeylerinin değerlendirilmesi. Gereç ve Yöntemler: Çalışmaya kırk PKOSlu hasta ve 35 sağlıklı kontrol dahil edildi. Her olguda serumda TSA, LBSA, folikül stimülan hormon, luteinizan hormon, östradiol, tiroid stimülan hormon, prolaktin, dehidroepiandrosteron sülfat, androstenedion, serbest testosteron, total testosteron, 17-OH progesteron, seks hormon bağlayıcı globulin, kortizol, total kolesterol, trigliserid, yüksek densiteli lipoprotein ve düşük densiteli lipoprotein ölçüldü. Açlık insülin seviyesi, açlık glükozu/insülin oranı ve 2 saatlik 75-g glükoz tolerans testi ile insülin rezistansı değerlendirildi. Bulgular: Serum TSA seviyeleri açısından gruplar arasında anlamlı fark yoktu. Kontrol grubuna göre karşılaştırıldığında PKOSlu hastalarda serum LBSA seviyeleri yüksekti. PKOS grubunda TSA, androstenedione ve HOMA-IR ile korele bulundu. PKOSlu hastalarda LBSA ile dehidroepiandrosteron sulfat arasında pozitif korelasyon bulundu. BMIya göre düzeltme sonrası, kalan tek anlamlı korelasyon LBSA ile folikül stimülan hormon arasında idi. Sonuç: Kardiyovasküler hastalıklarda ve diabette arttığı bilinen LBSAnın serum seviyeleri PKOSda yükselir.

Abstract

Objective: To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS). Material and Methods: Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours. Results: Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone. Conclusion: Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS.

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Bu Makaleye Atıf Yap

ÇAĞLAYAN, O., SAĞSÖZ, N., YÜCEL, A., NOYAN, V., ÖZCAN, A. (2022). Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome. Journal of the Turkish-German Gynecological Association, Cilt: 13 - Sayı: 2, 79–84. https://ajindex.com/articles/567670

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Kaynakça (16)

  1. Carmina E, Lobo RA. Do hyperandrogenic women with normal menses have polycystic ovary syndrome? Fertil Steril 1999; 71: 319-22
  2. Wild RA, Painter PC, Coulson PB, Carruth KB, Ranney GB. Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome. J Clin End Met 1985; 61: 946-51
  3. Hopkinson EC, Satar N, Fleming R, Greer IA. Polycsytic ovary syndrome: the metabolic syndrome comes to gynecology. BMJ 1998; 317: 329-32
  4. Cook GM. Techniques for the analysis of membrane carbohydrates. In: Maddy AH. ed. Biochemical analysis of membranes. 1st ed. London: Wiley & Sons 1976; 287-92
  5. Schauer R. Chemistry, metabolism and biological function of sialic acids. Adv Carbohydr Chem Biochem 1982; 40: 131-234
  6. Succari M, Foglietti MJ, Percheron F. Perchlorosoluble glycoproteins and myocardial infarct: modifications of the carbohydrate moiety. Pathol Biol (Paris) 1982; 30: 151-4
  7. Tomino Y, Inoue W, Yagame M, Nomoto Y, Sakai H, Ito K, et al. Measurement of sialic acid and acute phase reactant proteins in sera of patients with diabetic nephropathy. J Diabet Complications 1988; 2: 75-8
  8. Taniuchi K, Chifu K, Hayashi N, Nakamachi Y, Yamaguchi N, Miyamoto Y, et al. A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants. Kobe J Med Sci 1981; 27: 91-102
  9. Stryer L. Biochemistry. 3rd ed. W. H. Freeman and Co. New York 1988
  10. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-7
  11. Katopodis N, Hirshaut Y, Geller NL, Stock CC. Lipid-associated sialic acid test for the detection of human cancer. Cancer Res 1982; 42: 5270-5
  12. Plucinsky MC, Riley WM, Prorok JJ, Alhadeff JA. Total and lipidassociated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement. Cancer 1986; 58: 2680-5
  13. Lindberg G, Ecklund GA, Gullberg B, Rastam L. Serum sialic acid concentration and cardiovascular mortality. BMJ 1991; 302: 143-6
  14. Crook MA, Treloar A, Haq M, Tutt P. Serum sialic acid and acute phase proteins in elderly subjects. Eur J Clin Chem Clin Biochem 1994; 32: 745-7
  15. Bickerton AS, Clark N, Meeking D, Shaw KM, Crook M, Lumb P, et al. Cardiovascular risk in women with polycystic ovarian syndrome (PCOS). J Clin Pathol 2005; 58: 151-4
  16. Hag M, Hag