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AI InsightBulgular: PKOS hastalarında ve kontrol grubunda TSH düzeyinde (1.9±1.8 vs. 1.2 μIU/mL±0.9 μIU/mL, p>0.05) anlamlı fark yoktu.
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Özet
Amaç: Bu çalışmanın amacı, polikistik over sendromu (PKOS) olan hastalarda tiroid dışı hastalık sendromunun (NTIS) sıklığını tespit et- mektir. Gereç ve Yöntemler: PKOSlu 52 hasta 6 aylık bir dönemde bu ke- sitsel çalışmaya alındı. Kontrol grubuna yaş uyumlu 68 gönüllü kadın dahil edildi. Serum serbest triyodotironin (sT3), serbest tiroksin (sT4), tiroid uyarıcı hormon (TSH), anti-tiroperoksidaz antikoru (anti-TPO Ab) ve anti-tiroglobulin antikoru (anti-Tg Ab ) ölçüldü. Bulgular: PKOS hastalarında ve kontrol grubunda TSH düzeyinde (1.9±1.8 vs. 1.2 μIU/mL±0.9 μIU/mL, p>0.05) anlamlı fark yoktu. Kont- rol grubunda serum sT3 ve sT4 düzeyleri PKOS hastalarınınkinden anlamlı olarak daha düşüktü (fT3: 2.7±0.3 pg/mL vs. 2.9±0.3 pg/mL, p=0.02; fT4: 1.0±0.1 ng/dL vs. 1.1±0.1 ng/dL, p=0.03). Hs-CRP (yük- sek hassas C-reaktif protein) ve sT4 arasında istatistiksel olarak an- lamlı ilişki gözlendi (r=0.245, p=0.015). Ancak NTIS iki grupta da göz- lenmedi. Sonuç: Tiroid fonksiyon bozuklukları PKOSta gözlenebilir ancak PKOS hastalarındaki inflamatuar duruma rağmen bu çalışmada NTIS tespit edilmedi. (J Turkish-German Gynecol Assoc 2013; 14: 216-20) Anahtar kelimeler:
Abstract
Objective: The aim of this study was to determine the frequencyof non-thyroidal illness syndrome (NTIS) in patients with polycysticovary syndrome (PCOS).Material and Methods: During a 6-month period, 52 patients withPCOS were recruited for this cross-sectional study. The control groupincluded 68 age-matched female volunteers. Serum free triiodothyro-nine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH),anti-thyroperoxidase antibody (anti-TPO Ab), and anti-thyroglobulinantibody (anti-Tg Ab) were measured.Results: The TSH level in the PCOS patients and controls did not dif-fer significantly (1.9±1.2 μIU/mL vs. 1.8±0.9 μIU/mL, p>0.05). SerumfT3 and fT4 levels in the controls were significantly lower than thosein the PCOS patients (fT3: 2.7±0.3 pg/mL vs. 2.9±0.3 pg/mL, p=0.02;fT4: 1.0±0.1 ng/dL vs. 1.1±0.1 ng/dL, p=0.03). The Hs-CRP (high-sen-sitivity C-reactive protein) level in the PCOS patients was significantlyhigher than in the controls (3.5±4.9 mg/L vs. 1.7±2.7 mg/L, p=0.03).A statistically significant relationship was observed between Hs-CRPand fT4 (r=0.245, p=0.015). However, NTIS was not observed in ei-ther group.Conclusion: Thyroid function abnormalities could be observed inPCOS; however, NTIS was not noted in the present study despite theinflammatory state of the PCOS patients.(J Turkish-German Gynecol Assoc 2013; 14: 216-20)