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Dergiler / Joint diseases and related surgery / 2020 / Cilt: 31 - Sayı: 3

Tranexamic acid has positive effect in early period of tendon healing by stimulating the tumor necrosis factor-alpha and matrix metalloproteinase-3 expression levels

Orhan BAŞ
Havva ERDEM
Abdullah Alper ŞAHİN
Alper ÇIRAKLI
Pınar Naile GÜRGÖR
Erdal UZUN
Sayfa
463–469
Yayın Tarihi
2022-10-19
DOI
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Results: In TNF-α and MMP-3 and TXA groups, there was a significant difference in staining compared to SP groups (p

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Amaç & Hipotez:Objectives: This study aims to evaluate the effect of tranexamic acid (TXA) application in tendon healing by using its immunohistochemical effects on tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-3 (MMP-3), and transforming growth factor-beta (TGF-β) expression; and to identify if TNF-α, MMP-3, and TGF-β can be used to monitor and evaluate tendon healing or not in tenotomized rat Achilles tendons.
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Temel Bulgular & Veri:Materials and methods: Twelve male Wistar-Albino rats (age 6-7-month-old; weighing 300-350 g) were used in this retrospective study conducted between November 2016 and May 2017.
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Sonuç & Katkı:Results: In TNF-α and MMP-3 and TXA groups, there was a significant difference in staining compared to SP groups (p
🔬Tür:Araştırma Makalesi
📍Kapsam:2016 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

Objectives: This study aims to evaluate the effect of tranexamic acid (TXA) application in tendon healing by using its immunohistochemical effects on tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-3 (MMP-3), and transforming growth factor-beta (TGF-β) expression; and to identify if TNF-α, MMP-3, and TGF-β can be used to monitor and evaluate tendon healing or not in tenotomized rat Achilles tendons. Materials and methods: Twelve male Wistar-Albino rats (age 6-7-month-old; weighing 300-350 g) were used in this retrospective study conducted between November 2016 and May 2017. The rats were divided into two groups with similar weights. The right legs of the rats were determined as the study group (TXA), and the left legs as the control serum physiologic (SP) group. Under anesthesia, bilateral Achilles tenotomy was performed and surgically repaired. 1 mL of TXA was applied locally for the right side and 1 mL of SP was locally applied for the left side. Half of the rats were sacrificed at the third week (right leg-TXA3, left leg-SP3) and the other half at sixth week (right leg-TXA6, left leg-SP6) and tendon samples were taken from the extremities. Immunohistochemical findings of TNF-α, MMP-3, and TGF-β were evaluated on the basis of the frequency and intensity of staining. Results: In TNF-α and MMP-3 and TXA groups, there was a significant difference in staining compared to SP groups (p

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Bu Makaleye Atıf Yap

BAŞ, O., ERDEM, H., ŞAHİN, A. A., ÇIRAKLI, A., GÜRGÖR, P. N., UZUN, E. (2022). Tranexamic acid has positive effect in early period of tendon healing by stimulating the tumor necrosis factor-alpha and matrix metalloproteinase-3 expression levels. Joint diseases and related surgery, Cilt: 31 - Sayı: 3, 463–469. https://ajindex.com/articles/559331

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Kaynakça (13)

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