Dergiler / IUFS Journal of Biology / 2008 / Cilt: 67 - Sayı: 2

The effects of propylthiouracil on small intestine of mice: a light and electron microscobical study

Sayfa
129–134
Yayın Tarihi
2022-10-18
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a result, we can conclude that PTU causes significant structural changes and stimulates itssynthesis and secretion functions in the small intestinal epithelium

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, the effect of propylthiouracil on epithelial cells of the small intestine is examined by histologicaland cytological methods.
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Temel Bulgular & Veri:As a result of histologic analyses an increase in PAS positive reaction was observed inthe intestinal epithelium of the experimental group given PTU for 1 month.
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Sonuç & Katkı:As a result, we can conclude that PTU causes significant structural changes and stimulates itssynthesis and secretion functions in the small intestinal epithelium
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

In this study, the effect of propylthiouracil on epithelial cells of the small intestine is examined by histologicaland cytological methods. As a result of histologic analyses an increase in PAS positive reaction was observed inthe intestinal epithelium of the experimental group given PTU for 1 month. As a result of cytologic examination,administration of PTU for 1 month to rats induced marked ultrastructural changes in the small intestinalepithelium. As a result, we can conclude that PTU causes significant structural changes and stimulates itssynthesis and secretion functions in the small intestinal epithelium

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Bu Makaleye Atıf Yap

BULAN, Ö. K. (2022). The effects of propylthiouracil on small intestine of mice: a light and electron microscobical study. IUFS Journal of Biology, Cilt: 67 - Sayı: 2, 129–134. https://ajindex.com/articles/544083

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Kaynakça (12)

  1. Bancroft J.D and Stevens A. (1982). Theory and practica of histological techniques. Churchill Livingstone, Edinburgh,. Ben Hamida F., Soussia L., Guermazi F., Rebai T. And Zeghal N. (2001). Propythiouracil and perchlorate effects on thyroid function in young and lactating mice. Ann Endocrinol (Paris), 62(5):446-53.
  2. Bronk J.R. and Parsons DS. (1994). Influence of the thyroid gland on the accumulation of sugars in rats intestinal mucosa during adsorbtion. J.Physiol., 179:107-115.
  3. Brtko J., Pascual A. and Aranda A. (1994). 3,5,3/- Triiodothyronine nuclear reseptors and their role in the thyroid hormone action. Endocr. Reg., 28:107-115.
  4. Bulan Ö.K. (1999). The effects of thyroid hormones on the epithelial cells of the small intestine. University of Istanbul Journal of Biology, 61/62:1-23.
  5. Dahlquist A., Olson I. and Norden A. (1965). The periodate-schift reaction: Specifity, kinetics and reaction products with pure substrates. J. Histocem. Cytochem., 13(6): 423-430.
  6. Dhong H.J., Kim H.Y. and Ha B.S. (2003). Histologic changes to olfactory epithelium in hypothyroid rats. Otolaryngol Head Neck Surg., 129(1):24-32.
  7. Gilbert M.E. and Paczkowski C. (2003). Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus. Brain Res Dev Brain Res. 145(1):19-29.
  8. Hang X.W. Yang R.I., Zhao Z.Y., Ji C. and Yang R.W. (2005). Mechanism for apoptosis of hippocampus neuron induced by hypothyroidism in perinatal rats. Zhejiang Da Xue Bao yi Xue Ban., 34(4):298-303.
  9. Hays MT.(1970). Absorption of triiodothyroinine in man. J. Clin. Endocr., 30:675-677.
  10. Hays M.T. (1988). Thyroid Hormone and the Gut. Endocrine Research. 14 (2,3): 203- 224. Hodin R.A, Chamberlain S.M. and Upton M.P. (1992). Thyroid hormone differentially regulates rat intestinal brush border enzyme gene expression. Gastroenterelogy, 103(5):1523-1536.
  11. Hodin R.A, Shei A, Morin M. and Meng S. (1996). Thyroid hormone and the gut: Selective transcriptional activation of a villus-entereocyte marker. Surgery, 120(2) 138-143.
  12. Israel E.J., Pang K.Y., Harmatz P.R. and Walker W.A. (1987). Structural and functional maturation of rat gastrointestinal barrier with thyroxine. Am. J. Physiol., 252 (6,pt1) G762- G767. Levin R.J. (1974). A brief overwiew of the influence of the thyroid on intestinal function. Dowling HR, Riecken EO. Intestinal adaptation. Proceedings of an International Conferance on the Anatomy, 253-261. Middleton W.R.J. and M