KaydedilenlerDerginizi ekleyin

Dergiler / Hittite Journal of Science and Engineering / 2019 / Cilt: 6 - Sayı: 3

The Preventive Effect of Thymoquinone and Ceratonia Siliqua L. in Experimental Asthmatic Pregnant Rats: Histologically and Immunohistochemically Evaluation

Sule Coskun Cevher
Ameerah Fadhil Ahmed
Sayfa
215–222
Yayın Tarihi
2022-10-18
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The use of TQ and CS in people withnormal asthma may be used as a new promising supplement to eliminate the negative effects of asthma

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:T here are no studies yet have been compared pregnant rat asthma models by assessing the airway both histologically and immunohistochemically under the effect of Thymoquinone TQ and Ceratonia siliqua CS Carob .
📊
Temel Bulgular & Veri:To compare asthmatic pregnant models with TQ and CS by studying changes of both the histologically and the immunohistochemically of lung tissue using light microscopy. 18 female wistar rats were randomly split to 3 groups: asthmatic pregnant group I sensitized by intraperitoneal ovalbumin injection OVA with alum on days 0 and 14 and submitted to OVA aerosolized 3 days in excess of the next 1 week then they coupled with male rats to get pregnancy; asthmatic pregnant with TQ and CS group II sensitized as above then they administered each of TQ and CS on the last 5 days of pregnancy; and asthmatic pregnant with dexamethasone group III that received dexamethasone by intraperitoneal injection on last 5 days of pregnancy.Lung tissue immunohistochemically and histologically were evaluated.
💡
Sonuç & Katkı:The use of TQ and CS in people withnormal asthma may be used as a new promising supplement to eliminate the negative effects of asthma
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Rats · Asthma · Remodeling

Abstract

T here are no studies yet have been compared pregnant rat asthma models by assessing the airway both histologically and immunohistochemically under the effect of Thymoquinone TQ and Ceratonia siliqua CS Carob . To compare asthmatic pregnant models with TQ and CS by studying changes of both the histologically and the immunohistochemically of lung tissue using light microscopy. 18 female wistar rats were randomly split to 3 groups: asthmatic pregnant group I sensitized by intraperitoneal ovalbumin injection OVA with alum on days 0 and 14 and submitted to OVA aerosolized 3 days in excess of the next 1 week then they coupled with male rats to get pregnancy; asthmatic pregnant with TQ and CS group II sensitized as above then they administered each of TQ and CS on the last 5 days of pregnancy; and asthmatic pregnant with dexamethasone group III that received dexamethasone by intraperitoneal injection on last 5 days of pregnancy.Lung tissue immunohistochemically and histologically were evaluated. Various histological changes in lung tissues of group I were revealed. However, treatment of TQ and CSwas prevented these changes in group II. Immunohistochemically, vascular endothelialgrowth factor VEGF staining levels increase was observed in group I, while there was asignificant decrease in group II than it is in group III. In this study, the use of TQ and CS has been shown to alleviate the histological changes and immunohistochemically causedby asthma. In conclusion, TQ and CS was thought to be a promising treatment agent forasthma in the future especially during pregnancy. The use of TQ and CS in people withnormal asthma may be used as a new promising supplement to eliminate the negative effects of asthma

🔖

Bu Makaleye Atıf Yap

Cevher, S. C., Ahmed, A. F. (2022). The Preventive Effect of Thymoquinone and Ceratonia Siliqua L. in Experimental Asthmatic Pregnant Rats: Histologically and Immunohistochemically Evaluation. Hittite Journal of Science and Engineering, Cilt: 6 - Sayı: 3, 215–222. https://ajindex.com/articles/538002

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (18)

  1. Hansel TT, Barnes PJ. Novel drugs for treating asthma. Curr Allergy Asthma Rep 2001;1:164-73
  2. Tagaya E, Tamaoki J. Mechanisms of airway remodeling in asthma. Allergol Int. 2007;56:331-40
  3. Herz U, Renz H, Wiedermann U. Animal models of type I allergy using recombinant allergens. Methods. 2004;32:271-80
  4. Zosky GR, Sly PD. Animal models of asthma.Clin Exp Allergy. 2007;37:973-88
  5. Ramos-Barbón D, Ludwig MS, Martin JG. Airway remodeling: lessons from animal models. Clin Rev Allergy Immunol. 2004;27:3- 21
  6. Arm JP, Lee TH. The pathobiology of bronchial asthma. Adv Immunol 1992; 51:323-82
  7. Gleich GJ, Adolphson CR. The eosinophilic leukocyte: structure and function. Adv Immunol 1986; 39:177-253
  8. Sumi Y, Hamid Q. Airway remodeling in asthma. Allergol Int 2007;56:341-8
  9. Atta-ur-Rahman, Malik S, Ahmed S, Choudhary MI, Habib-urRehman. Nigellimine-N-oxide A new isoquinoline alkaloid from the seeds of Nigella sativa. Heterocycles 1985; 23:953-5
  10. Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: Potential Cure for Inflammatory Disorders and Cancer. Biochem Pharmacol 2012; 83: 443-51
  11. Ammar el SM, Gameil NM, Shawky NM, Nader MA. Comparative evaluation of anti-inflammatory poperties of thymoquinone and curcumin using an asthmatic murine model. Int Immunopharmacol 2011; 11: 2232-6
  12. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 2006; 6: 113542
  13. Al-Gahmdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001;76:45–8
  14. Sidina MM., El Hansali M, Wahid N, Ouatmane A, Boulli A, Haddioui A. Fruit and seed diversity of domesticated carob (Ceratonia siliqua L.) in Morocco. Scientia Horticulturae. 2009; 123: 110-116
  15. Luthria D. Significance of sample preparation in developing analytical methodologies for accurate estimation of bioactive compounds in functional foods. Journal of the Science of Food and Agriculture2006; 86: 2266-2272
  16. Anonim. Ulusal Gida Kompozisyon Veri Tabanı. 2017; www. turkomp.gov.tr/food/376 (Access Date: 11.07. 2017)
  17. Youssef, M. K. E., El-Manfaloty, M. M., & Ali, H. M. Assessment of proximate chemical composition, nutritional status, fatty acid composition and phenolic compounds of carob (Ceratonia siliqua L.). Healthcare Foodservice Magazine. 2013; 3, 304–308
  18. Karhan, M., H. Gubbuk, İ. Turhan, H. R. Öziyci, H. Akgül,