Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightBesides a statistically significant relationship was found betweenloss of ARID1A, and the presence of both in situ component (p=0.016) and lymph node metastasis (p=0.001).Conclusion: In this study, we have demonstrated that loss of ARID1A expression positively correlates with hormone receptor status as well astumor aggressiveness.
📌 3 Maddede Bu Makale
Abstract
Objective: Breast cancer is the most common cancer among women worldwide. Adenine thymine-rich interactive domain 1A (ARIDIA) is a tumorsuppressor gene involved in chromatin remodeling and it encodes the ARIDIA protein. Recent studies have shown the loss of ARIDIA proteinexpression in different carcinomas may have a prognostic significance. In the present study, we aimed to evaluate the interactions between ARIDIAloss and molecular subtypes of breast carcinomas.Materials and Methods: ARIDIA expressions were studied in 292 formalin- fixed, paraffin- embedded breast carcinoma specimens and its associationwith different pathological and clinical parameters was evaluated.Results: Loss of ARIDIA expression was detected in 123 cases. There was no statistically significant association between ARID-1A expression andmolecular subtype of breast carcinomas (p=0.110) or HER2 amplification (p=0.909). Contrarily, there was a significant association between ARIDIAexpression and presence of estrogen (p=0.047) or progesterone receptors (p=0.023). Besides a statistically significant relationship was found betweenloss of ARID1A, and the presence of both in situ component (p=0.016) and lymph node metastasis (p=0.001).Conclusion: In this study, we have demonstrated that loss of ARID1A expression positively correlates with hormone receptor status as well astumor aggressiveness.