Dergiler / İzmir Tepecik Eğitim Hastanesi Dergisi / 2019 / Cilt: 29 - Sayı: 2

Effectiveness of Radiological Findings of Gastrointestinal Stromal Tumors in the Prediction of High-Risk Potential for Malignancy

Gastrointestinal Stromal Tümörlerin Radyolojik Bulgularının Malignite Potansiyelini Öngörmedeki Etkinliği

Sayfa
148–156
DOI
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Tumor size and central hypodensity may provide risk stratification according to the NIH criteria.

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Amaç & Hipotez:Objective: The purpose of our study was to investigate the effectiveness of radiological findings in the prediction of malignancy potential in gastrointestinal stromal tumors according to the National Institutes of Health and the Armed Forces Institute of Pathology criteria.
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Temel Bulgular & Veri:Methods: In our study 50 patients who were diagnosed pathologically as gastrointestinal stromal tumors between January 2010 and January 2018 were evaluated retrospectively.
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Sonuç & Katkı:Tumor size and central hypodensity may provide risk stratification according to the NIH criteria.
🔬Tür:Araştırma Makalesi
📍Kapsam:2010 Verileri
⚙️Değişkenler:Alan Parametreleri

Özet

Objective: The purpose of our study was to investigate the effectiveness of radiological findings in the prediction of malignancy potential in gastrointestinal stromal tumors according to the National Institutes of Health and the Armed Forces Institute of Pathology criteria. Methods: In our study 50 patients who were diagnosed pathologically as gastrointestinal stromal tumors between January 2010 and January 2018 were evaluated retrospectively. Twenty-seven patients were excluded from the study because their preoperative computed tomography results could not be reached. We evaluated preoperative computed tomography examinations of 23 patients included in the study with gastrointestinal stromal tumors according to size, contour, central hypoattenuation, homogeneity, contrast enhancement, growth pattern, mesen- teric heterogeneity, local invasion to surrounding tissues, cavitation, concomitant presence of lymphadenopathy lar- ger than 1 cm, fluid collection and metastasis. Radiological findings were compared with histopathologic findings, and the effectiveness of radiological findings on the prediction of malignancy potential was evaluated according to the National Institutes of Health and the Armed Forces Institute of Pathology criteria. Univariate and multivariate logistic regression analyses were used and p<0.05 was accepted as the level of statistical significance. Results: Tumor size (p=0.023) and central hypodensity (p=0.036) were found to be statistically significant for risk stratification according to the National Institutes of Health criteria. Contour irregularity (p=0.036, p=0.026) and mesenteric heterogeneity (p=0.021, p=0.005) were found to be statistically significant in decreasing importance in the evaluation of high risk potential according to the National Institutes of Health and the Armed Forces Institute of Pathology criteria, respectively. Conclusion: Contour irregularity and mesenteric heterogeneity may be useful to predict the high risk potential according to the both criteria. Tumor size and central hypodensity may provide risk stratification according to the NIH criteria.

Abstract

Amaç: Çalışmamızın amacı gastrointestinal stromal tümörlerin radyolojik bulgularının malignite potansiyelini öngörmedeki etkinliğinin National Institutes of Health ve Armed Forces Institute of Pathology kritlerine göre araştırılmasıdır. Yöntem: Çalışmamızda Ocak 2010-Ocak 2016 tarihleri arasında patolojik olarak gastrointestinal stromal tümör tanısı almış 50 hasta rerospektif olarak incelenmiştir. Yirmi yedi hasta preoperatif bilgisayarlı tomografi tetkiklerine ulaşılamadığından çalışma dışı bırakılmıştır. Çalışmaya dahil olan 23 hastanın preoperatif bilgisayarlı tomografi tetkiklerinde tümörler boyut, kontur özellikleri, homojenite, kontrastla boyanma şekli, santral hipoatenüasyon varlığı, büyüme paterni, mezenterik heterojenite, çevre dokulara invazyon, kavitasyon, eşlik eden batın içi serbest sıvı, eşlik eden karaciğer metastazı ve 1 cm’den büyük lenf nodunun varlığı açısından değerlendirilmiştir. Radyolojik bulgular histopatolojik bulgular ile kıyaslanmış ve radyolojik bulguların malignite potansiyelini öngörmedeki etkin- likleri araştırılmıştır. Tek değişkenli ve çok değişkenli lojistik regresyon analizleri kullanılmış ve p<0,05 olması anlamlı kabul edilmiştir. Bulgular: Yirmi üç hasta ile yaptığımız çalışmamızda tümör boyutu (p=0,023) ve santral hipodansite varlığı (p=0,036) National Institutes of Health kriterlerine göre risk grubunu belirlemede anlamlı bulundu. Kontur düzensizliği (p=0,036, p=0,026) ve mezenterik heterojenite (p=0,021, p=0,005) ise sırasıyla hem National Institutes of Health hem de Armed Forces Institute of Pathology kritelerine göre yüksek risk varlığını belirlemede anlamlı olarak bulundu. Sonuç: Sonuç olarak, kontur düzensizliği ve mezenterik heterojenite yüksek risk varlığını ön görmede yol gösterici olabilmektedir. Tümörlerin radyolojik olarak benign ve malign olma özellikleri tedavi ve takip sürecinde hastalar için önemli farklar yarattığından, çalışmamızın bu süreçlerde önemli yarar sağlayacağını düşünmekteyiz.

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Bu Makaleye Atıf Yap

SARIOĞLU, F. C., ÖNCEL, D., SARIOĞLU, O., BİRANCI, A. I., ÜNLÜ, A. G. D. (2019). Effectiveness of Radiological Findings of Gastrointestinal Stromal Tumors in the Prediction of High-Risk Potential for Malignancy. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 29 - Sayı: 2, 148–156. https://ajindex.com/articles/189860

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Kaynakça (12)

  1. Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M. Gastrointestinal stromal tumors: radiologic features with pathologic correlation. Radiographics. 2003;23(2):283-304.
  2. Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S. Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognosticclassification based on tumor size and MIB-1 grade. Hum Pathol. 2002;33(6):669- 76. Miettinen M, El-Rifai W, H L Sobin L, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002;33(5):478-83.
  3. Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol. 1999;30(10):1213-20.
  4. Kim HC, Lee JM, Kim KW, Park SH, Kim SH, Lee JY, et al. Gastrointestinal stromal tumors of the stomach: CT findings and prediction of malignancy. AJR Am J Roentgenol. 2004;183(4):893-8.
  5. Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, et al. Gastrointestinal stromal tumors/ smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23(9):1109-18.
  6. Chourmouzi D, Sinakos E, Papalavrentios L, Akriviadis E, Drevelegas A. Gastrointestinal stromal tumors: a pictorial review. J Gastrointestin Liver Dis. 2009;18(3):379-83.
  7. Kim MN, Kang SJ, Kim SG, Im JP, Kim JS, Jung HC, et al. Prediction of risk of malignancy of gastrointestinal stromal tumors by endoscopic ultrasonography. Gut Liver. 2013;7(6):642-7.
  8. Mei L, Smith SC, Faber AC, Trent J, Trent J, Grossman SR, et al. Gastrointestinal Stromal Tumors: The GIST of Precision Medicine. Trends Cancer. 2018;4(1):74-91.
  9. Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70-83.
  10. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 2002;33(5):459- 65. Pelandré GL, Djahjah MC, Gasparetto EL, Nacif MS, Marchiori E, Mello EL. Tomographic findings of gastric gastrointestinal stromal tumor and correlation with the mitotic index. Arq Gastroenterol. 2013;50(4):244-50.
  11. Yang TH, Hwang JI, Yang MS, Hung SW, Chan SW, Wang J, et al. Gastrointestinal stromal tumors: computed tomographic features and prediction of malignantrisk from computed tomographic imaging. J Chin Med Assoc. 2007;70(9):367-73.
  12. Khoo CY, Chai X, Quek R, Teo MCC, Goh BKP