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Dergiler / European Journal of Breast Health / 2020 / Cilt: 16 - Sayı: 1

Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer

Ece MİSER SALİHOĞLU
Sevgi YARDIM AKAYDIN
Dilek GELEN GÜNGÖR
Hasan KARANLIK
Semra DEMOKAN
Sayfa
72–76
Yayın Tarihi
2022-10-18
DOI
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GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p

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Amaç & Hipotez:Objective: The gamma-glutamyl cycle catalyzed by gamma-glutamyl transferase (GGT) plays an important role in glutathione (GSH) homeostasis inthe cell.
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Temel Bulgular & Veri:In this study,we aimed to investigate the relationship between GGT and GSH in molecular subgroups of breast cancer patients.Materials and Methods: Serum GGT activity and GSH levels for patients diagnosed with breast cancer (n=58) and healthy controls (n=8) weremeasured by a spectrophotometric method and a colorimetric kit, respectively.Results: GGT activity was significantly higher in the total patient group and in the molecular subgroups than those in the control groups (p0.05).
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Sonuç & Katkı:GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: The gamma-glutamyl cycle catalyzed by gamma-glutamyl transferase (GGT) plays an important role in glutathione (GSH) homeostasis inthe cell. In cells continuously exposed to the drug, the main phase of the enzymatic detoxification is the conjugation of the drug with GSH catalyzed byglutathione-S-transferase (GST). Conjugation of drugs with GSH is the first step in the development of chemotherapeutic drug resistance. In this study,we aimed to investigate the relationship between GGT and GSH in molecular subgroups of breast cancer patients.Materials and Methods: Serum GGT activity and GSH levels for patients diagnosed with breast cancer (n=58) and healthy controls (n=8) weremeasured by a spectrophotometric method and a colorimetric kit, respectively.Results: GGT activity was significantly higher in the total patient group and in the molecular subgroups than those in the control groups (p0.05). GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p

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Bu Makaleye Atıf Yap

SALİHOĞLU, E. M., AKAYDIN, S. Y., GÜNGÖR, D. G., KARANLIK, H., DEMOKAN, S. (2022). Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer. European Journal of Breast Health, Cilt: 16 - Sayı: 1, 72–76. https://ajindex.com/articles/510764

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Kaynakça (15)

  1. Fornaciari I, Fierabracci V, Corti A, Aziz Elawadi H, Lorenzini E, Emdin M, Paolicchi A, Franzini M. Gamma-Glutamyltransferase Fractions in Human Plasma and Bile: Characteristic and Biogenesis. PLoS One 2014; 9: e88532. (PMID: 24533101
  2. Heisterkamp N, Groffen J, Warburton D, Sneddon TP. The human gamma-glutamyltransferase gene family. Hum Genet 2008; 123: 321-332. (PMID: 18357469
  3. Owen AD, Schapira AH, Jenner P, Marsden CD. Oxidative stress and Parkinson’s disease. Ann N Y Acad Sci 1996; 786: 217-223. (PMID: 8687021
  4. Kadoğlu D, Akçay T. Glutation Metabolism and Clinical Importance. Turkiye Klinikleri Journal of Medical Sciences 1995; 15: 214-218
  5. Wickham S, West MB, Cook PF, Hanigan MH. Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem 2011; 414: 208-214. (PMID: 21447318
  6. Ribas V, García-Ruiz C, Fernández-Checa JC. Glutathione and mitochondria. Front Pharmacol 2014; 5: 151. (PMID: 25024695
  7. Lu SC. Regulation of glutathione synthesis. Mol Aspects Med 2009; 30: 42-59. (PMID: 18601945
  8. Wang Y, Li J, Matye D, Zhang Y, Dennis K, Ding WX, Li T. Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury. JCI Insight 2018; 3: 99676. (PMID: 29669937
  9. Ball EG, Cooper O, Revel JP. The quantitative measurement of gamma glutamyl transpeptidase activity. J Biol Chem 1956; 221: 895-908. (PMID: 13357485
  10. Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38: 263-355. (PMID: 11563810
  11. Estrela JM, Ortega A, Obrador E. Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 2006; 43: 143-181. (PMID: 16517421
  12. Hanigan MH. Gamma-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis. Chem Biol Interact 1998; 111-112: 333-42. (PMID: 9679564
  13. Banneau G, Guedj M, MacGrogan G, de Mascarel I, Velasco V, Schiappa R, Bonadona V, David A, Dugast C, Gilbert-Dussardier B, Ingster O, Vabres P, Caux F, de Reynies A, Iggo R, Sevenet N, Bonnet F, Longy M. Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations. Breast Cancer Res 2010; 12: R63. (PMID: 20712882
  14. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005; 205: 275-292. (PMID: 15641020
  15. Ramsay EE, Dilda PJ. Glutathione S-conjugates as prodrugs to target drug-resistant tumors. Front Pharmacol 2014; 5: 181. (PMID: 25157234