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Journals / European Journal of Breast Health / 2020 / Cilt: 16 - Sayı: 1

Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer

Ece MİSER SALİHOĞLU
Sevgi YARDIM AKAYDIN
Dilek GELEN GÜNGÖR
Hasan KARANLIK
Semra DEMOKAN
Pages
72–76
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The gamma-glutamyl cycle catalyzed by gamma-glutamyl transferase (GGT) plays an important role in glutathione (GSH) homeostasis inthe cell.
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Key Findings & Data:In this study,we aimed to investigate the relationship between GGT and GSH in molecular subgroups of breast cancer patients.Materials and Methods: Serum GGT activity and GSH levels for patients diagnosed with breast cancer (n=58) and healthy controls (n=8) weremeasured by a spectrophotometric method and a colorimetric kit, respectively.Results: GGT activity was significantly higher in the total patient group and in the molecular subgroups than those in the control groups (p0.05).
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Conclusion & Impact:GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The gamma-glutamyl cycle catalyzed by gamma-glutamyl transferase (GGT) plays an important role in glutathione (GSH) homeostasis inthe cell. In cells continuously exposed to the drug, the main phase of the enzymatic detoxification is the conjugation of the drug with GSH catalyzed byglutathione-S-transferase (GST). Conjugation of drugs with GSH is the first step in the development of chemotherapeutic drug resistance. In this study,we aimed to investigate the relationship between GGT and GSH in molecular subgroups of breast cancer patients.Materials and Methods: Serum GGT activity and GSH levels for patients diagnosed with breast cancer (n=58) and healthy controls (n=8) weremeasured by a spectrophotometric method and a colorimetric kit, respectively.Results: GGT activity was significantly higher in the total patient group and in the molecular subgroups than those in the control groups (p0.05). GGT activity was positivelycorrelated with GSH levels in the total patients and healthy controls (p

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Cite This Article

SALİHOĞLU, E. M., AKAYDIN, S. Y., GÜNGÖR, D. G., KARANLIK, H., DEMOKAN, S. (2022). Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer. European Journal of Breast Health, Cilt: 16 - Sayı: 1, 72–76. https://ajindex.com/articles/510764

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