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Dergiler / Bitlis Eren Üniversitesi Fen Bilimleri Dergisi / 2021 / Cilt: 10 - Sayı: 3

The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity in Rats

The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity In Rats

Burçin ÇELİKEZEN
Sadettin TANYILDIZI
Gökhan OTO
Sayfa
692–702
Yayın Tarihi
2021-09-17
DOI
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According to the results, MDA levels increased significantly in doxorubucin induced group (p

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Amaç & Hipotez:Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats.
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Temel Bulgular & Veri:In this study, 20 Wistar-Albino male rats were used.
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Sonuç & Katkı:According to the results, MDA levels increased significantly in doxorubucin induced group (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Boraks · Bor bileşikleri · Doksorubisin

Özet

Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p

Abstract

Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p

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Bu Makaleye Atıf Yap

ÇELİKEZEN, B., TANYILDIZI, S., OTO, G. (2021). The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity in Rats. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, Cilt: 10 - Sayı: 3, 692–702. https://ajindex.com/articles/477402

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