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Dergiler / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2019 / Cilt: 15 - Sayı: 4

Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR

Hale Seçilmiş Canbay
Mahmut Doğantürk
Sayfa
401–407
Yayın Tarihi
2022-10-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Study of drug–excipient interactions is a crucial step in preformulation stage of drug development toachieve consistent chemical, physical, bioavailability, manufacturability and stability of the dosage form.In pre-formulation studies, it is important to use thermoanalytical and spectroscopic methods.
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Temel Bulgular & Veri:Sildenafil is a well-tolerated and highly effectivetreatment for erectile dysfunction.
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Sonuç & Katkı:According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Study of drug–excipient interactions is a crucial step in preformulation stage of drug development toachieve consistent chemical, physical, bioavailability, manufacturability and stability of the dosage form.In pre-formulation studies, it is important to use thermoanalytical and spectroscopic methods. These areimportant systems for achieving a suitable formulation. Sildenafil is a well-tolerated and highly effectivetreatment for erectile dysfunction. Erectile dysfunction was revolutionized with the development of aselective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5.Thermogravimetric analysis, Differential Scanning Calorimetry, Fourier TransformInfrared Spectroscopy, and X-ray Powder Diffraction systems were used in the investigation and todetermine the possible interactions between sildenafil and some excipients like butylated hydroxyanisole,cellulose, sodium carboxymethyl cellulose, ascorbic acid, and citric acid. Binary mixtures ofdrug:excipient=1:1 (mass/mass) have been analyzed. According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.

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Bu Makaleye Atıf Yap

Canbay, H. S., Doğantürk, M. (2022). Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 15 - Sayı: 4, 401–407. https://ajindex.com/articles/472376

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Kaynakça (13)

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  13. Seçilmiş Canbay,