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Journals / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2019 / Cilt: 15 - Sayı: 4

Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR

Hale Seçilmiş Canbay
Mahmut Doğantürk
Pages
401–407
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.

📌 3 Key Takeaways

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Objective & Hypothesis:Study of drug–excipient interactions is a crucial step in preformulation stage of drug development toachieve consistent chemical, physical, bioavailability, manufacturability and stability of the dosage form.In pre-formulation studies, it is important to use thermoanalytical and spectroscopic methods.
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Key Findings & Data:Sildenafil is a well-tolerated and highly effectivetreatment for erectile dysfunction.
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Conclusion & Impact:According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Study of drug–excipient interactions is a crucial step in preformulation stage of drug development toachieve consistent chemical, physical, bioavailability, manufacturability and stability of the dosage form.In pre-formulation studies, it is important to use thermoanalytical and spectroscopic methods. These areimportant systems for achieving a suitable formulation. Sildenafil is a well-tolerated and highly effectivetreatment for erectile dysfunction. Erectile dysfunction was revolutionized with the development of aselective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5.Thermogravimetric analysis, Differential Scanning Calorimetry, Fourier TransformInfrared Spectroscopy, and X-ray Powder Diffraction systems were used in the investigation and todetermine the possible interactions between sildenafil and some excipients like butylated hydroxyanisole,cellulose, sodium carboxymethyl cellulose, ascorbic acid, and citric acid. Binary mixtures ofdrug:excipient=1:1 (mass/mass) have been analyzed. According to the results, there is incompatibilitywith butylated hydroxyanisole, ascorbic acid, and citric acid.

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Cite This Article

Canbay, H. S., Doğantürk, M. (2022). Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 15 - Sayı: 4, 401–407. https://ajindex.com/articles/472376

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References (13)

  1. Lue, T.F. 2000. Erectile dysfunction, The New England Journal of Medicine; 342: 1802-1813
  2. McMahon, C.G. 2002. High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction. International Journal of Impotence Research; 14: 533- 538
  3. Özgür, C.Ö, Gonenc, F, Yazicioglu, A.H. 2009. Sildenafil or vardenafil nonresponders’ erectile response to Tadalafil, Urology Journal; 6.4: 267-271
  4. Boolell, M, Allen, M.J, Ballard, S.A, Gepi-Attee, S, Muirhead, G.J, Naylor, A.M, Osterloh, I.H, Gingell, C. 1996. Sildenafil: an orally active type 5 cyclic GMPspecific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. International Journal of Impotence Research; 8: 47–52
  5. Webb, D.J, Freestone, S, Allen, M.J, Muirhead, G.J. 1999. Sildenafil citrate and blood-pressure–lowering drugs: Results of drug interaction studies with an organic nitrate and a calcium antagonist. The American Journal of Cardiologyt; 83. 5A: 21C-28C
  6. Verma, R.K, Garg, S. 2005. Selection of excipients for extended release formulations of glipizide through drug–excipient compatibility testing, Journal of Pharmaceutical and Biomedical Analysis; 38. 4: 633- 644
  7. Fathima, N, Mamatha, T, Qureshi, H.K, Anitha, N, Rao, J.V. 2011. Drug-excipients interaction and its importance in dosage form development. Journal of Applied Pharmaceutical Science; 1. 6: 66-71
  8. Bozag Pehlivian, S, Subaşi, B, Vural, I, Unlü, N, Capan, Y. 2011. Evaluation of drug-excipient interaction in the formulation of celecoxib tablets. Acta Poloniae Pharmaceutica; 68: 423-433
  9. Murthy, T.E.G.K, Bala Vishnu Priya M, Suresh Babu V.V. 2012. Compatibility studies of Acetazolamide with excipients by using High performance liquid chromatography. Indian drugs; 49. 05: 39-45
  10. Prathyusha, C.H, Murthy, T.E.G.K. 2013. Compatibility studies of Donepezil with different excipients by using HPLC and FTIR. Journal of Advanced Pharmacy Education & Research; 3. 3: 273-278
  11. Tulasi Baru, R, Bitla, P. 2017. Cyclobenzaprine drug assay and cyclobenzaprine-excipient interaction studyby chromatography, thermal and spectral analysis. Journal of Pharmaceutical Chemistry & Chemical Science; 1. 1: 1-9
  12. McDaid, F.M, Barker, S.A, Fitzpatrick, S, Petts, C.R, Craig, D.Q.M. 2003. Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug–excipient interactions. The International Journal of Pharmaceutics; 252. 1: 235-240
  13. Seçilmiş Canbay,