KaydedilenlerDerginizi ekleyin

Dergiler / Annals of Medical Research / 2021 / Cilt: 28 - Sayı: 11

Thymoquinone reduced RIPK1-dependent apoptosis caused by valproic acid in rat brain

Dilek Bayram
Sedat Bilgic
Deniz Tastemir Korkmaz
Sebile Azirak
Mehmet Kaya Ozer
Sayfa
2005–2011
Yayın Tarihi
2022-10-12
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Results: RIPK1 gene expression levels were significantly increased in the VPA group compared to the controls (p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Valproic acid (VPA) is a commonly used antiepileptic drug and known to have a neurotoxic effect, but its mechanism is not yet understood.
📊
Temel Bulgular & Veri:Materials and Methods: Male Sprague–Dawley albino rats were divided into three groups: control, VPA (500 mg/kg/day) and VPA + TQ (500 mg/kg/day + 50 mg/kg/day) with seven rats in.
💡
Sonuç & Katkı:Results: RIPK1 gene expression levels were significantly increased in the VPA group compared to the controls (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Aim: Valproic acid (VPA) is a commonly used antiepileptic drug and known to have a neurotoxic effect, but its mechanism is not yet understood. In the present study, we aimed to determine how the VPA causes cell death in the brain and to evaluate the protective effects of thymoquinone (TQ) on VPA-induced brain damage. Materials and Methods: Male Sprague–Dawley albino rats were divided into three groups: control, VPA (500 mg/kg/day) and VPA + TQ (500 mg/kg/day + 50 mg/kg/day) with seven rats in. At the end of the experiment, rats were sacrificed and brain samples were taken to measure the expression levels of Receptor-interacting serine/threonine-protein kinase-1 (RIPK1) and -3 (RIPK3) genes by quantitative real-time PCR (qRT-PCR), NADPH oxidase-4 (NOX4) and, caspase-3 (CAS-3) expression by immunohistochemistry and the structural changes in the brain tissue by histologically. Results: RIPK1 gene expression levels were significantly increased in the VPA group compared to the controls (p

🔖

Bu Makaleye Atıf Yap

Bayram, D., Bilgic, S., Korkmaz, D. T., Azirak, S., Ozer, M. K. (2022). Thymoquinone reduced RIPK1-dependent apoptosis caused by valproic acid in rat brain. Annals of Medical Research, Cilt: 28 - Sayı: 11, 2005–2011. https://ajindex.com/articles/445830

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Umka J, Mustafa S, ElBeltagy M, Thorpe A, Latif L, Bennett G, et al. Valproic acid reduces spatial working memory and cell proliferation in the hippocampus. NeuroSci 2010;166:15-22
  2. Tung EW, Winn LM. Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects. Mol Pharma 2011;80:979-87
  3. Fujiki R, Sato A, Fujitani M, Yamashita T. A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. Cell Death & Dis 2013;4:677-84
  4. Chen S, Wu H, Klebe D, Hong Y, Zhang J. Valproic acid: A new candidate of therapeutic application for the acute central nervous system injuries. Neurochem Res 2014;39:1621-33
  5. Zhang C, Zhu J, Zhang J, Li H, Zhao Z, Liao Y, et al. Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury. Brain Res 2014;1555:1-9
  6. Lovett M, Skidmore DL, Mohamed IS. Valproateinduced pseudoatrophy: Expanding the clinical and imaging spectrum. Pediatric Neurol 2014;51:284-5
  7. McLachlan RS. Pseudoatrophy of the brain with valproic acid monotherapy. Can J Neurol Sci 1987;14:294-6
  8. Galimberti CA, Diegoli M, Sartori I, Uggetti C, Brega A, Tartara A, et al. Brain pseudoatrophy and mental regression on valproate and a mitochondrial DNA mutation. Neurology 2006;67:1715-7
  9. Christensen J, Gronborg TK, Sorensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013;309:1696-703
  10. Bollino D, Balan I, Aurelian L. Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway. J Neurochem 2015;133:174-86
  11. Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SWG, et al. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ 2014;21:1511-21
  12. Liu Y, Liu T, Lei T, Zhang D, Du S, Girani L, et al. RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review). Int J Mol Med 2019;44:771-86
  13. Zhang D, Lin J, Han J. Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol 2010;7:243-9
  14. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010;22:263-8
  15. Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Le