Waste to wealth: agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thionesWaste to wealth: agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones
The obtained product is chromatographically pure after recrystallization from ethanol, and final product is characterized by various spectroscopic techniques FT-IR, 1H-, 13C-NMR and HR-MS.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:This paper describes novel agro-waste derived Water Extract of Orange Fruit Shell Ash (WEOFSA) catalyzed synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones under microwave irradiation.
📊
Temel Bulgular & Veri:Herein, we have developed inexpensive, facile and green method synthesis of cyclic thiones by the reaction of aromatic aldehyde and cyclic ketone, with thiosemicarbazide in presence of agro-waste derived catalyst.
💡
Sonuç & Katkı:The obtained product is chromatographically pure after recrystallization from ethanol, and final product is characterized by various spectroscopic techniques FT-IR, 1H-, 13C-NMR and HR-MS.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
This paper describes novel agro-waste derived Water Extract of Orange Fruit Shell Ash (WEOFSA) catalyzed synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones under microwave irradiation. Herein, we have developed inexpensive, facile and green method synthesis of cyclic thiones by the reaction of aromatic aldehyde and cyclic ketone, with thiosemicarbazide in presence of agro-waste derived catalyst. The obtained product is chromatographically pure after recrystallization from ethanol, and final product is characterized by various spectroscopic techniques FT-IR, 1H-, 13C-NMR and HR-MS.
🔖
Bu Makaleye Atıf Yap
KHATAVI, S. Y., KAMANNA, K. (2021). Waste to wealth: agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thionesWaste to wealth: agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones. Organic Communications, Cilt: 14 - Sayı: 3, 240–254. https://ajindex.com/articles/419570
Kaynakça (12)
Garrido-Castro, A. F.; Salaverri, N.; Maestro, M. C.; Aleman, J. Intramolecular homolytic substitution enabled by photoredox catalysis: sulfur, phosphorus, and silicon heterocycle synthesis from aryl halides. Org. Lett. 2019, 21, 5295-5300
Taylor, A. P.; Robinson, R. P.; Fobian, Y. M.; Blakemore, D. C.; Jones, L. H.; Fadeyi, O. Modern advances in heterocyclic chemistry in drug discovery. J. Med. Chem. 2014, 57, 5845-5859
Baumann, M.; Baxendale, I. R. An overview of the synthetic routes to the best-selling drugs containing 6- membered heterocycles. Beilstein J. Org. Chem. 2013, 9, 2265-2319
Kharb, K.; Chander, P.; Sharma Shahar, Y. M. Pharmacological significance of triazole scaffold. J. Enzyme Inhib. Med. Chem. 2011, 26, 1-21
Dheer, D.; Singh, V.; Shankar, R. Medicinal attributes of 1,2,3-triazoles: Current developments. Bioorg. Chem. 2017, 71, 30-54
Naito, Y.; Akahoshi, F.; Takeda, S.; Okada, T.; Kajii, M.; Nishimura, H.; Sugiura, M.; Fukaya, C.; Kagitani, Y. Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia. J. Med. Chem., 1996, 39, 3019-3029
Shafran, E. A.; Bakulev, V. A.; Rozin, Y. A.; Shafran, Y. M. Condensed 1,2,3-triazoles (Review). Chem. Heterocycl. Compd. 2008, 44, 1040-1069
Creary, X.; Anderson, A.; Brophy, B.; Crowell, F.; Funk, Z. Method for assigning structure of 1,2,3- triazoles. J. Org. Chem. 2012, 77, 8756-8761
Patil, S. B.; Krishnamurthy, G.; Shashikumar, N. D.; Lokesh, M. R.; Bhojya Naik, H. S. Synthesis and antimicrobial activity of some [1,2,4]-triazole derivatives. J. Chem., 2013, 1, 1-7
Kahnberg, P.; Lager, E.; Rosenberg, C.; Schougaard, J.; Camet, L.; Sterner, O.; Ostergaard, E. N.; Nielsen, M.; Liljefors, T. Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA receptor. J. Med. Chem. 2002, 45, 4188-4201
Cheng, H.; Wan, J.; Lin, M.; Liu, Y.; Lu, X.; Liu, J.; Xu, Y.; Chen, I.; Tu, Z.; Yih-Shyun, E. C.; Ding, K. design, synthesis, and in vitro biological evaluation of 1h-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza a agents targeting virus nucleoprotein. J. Med. Chem. 2012, 55, 2144-2153
Aneja, B.; Azam, M.; Alam, S.; Perwez, A.; Maguire, R.; Yadava, U.; Kavanagh, K.; Daniliuc, G. C.; Rizvi, A. M. M.; Mohd, Q.; Haq, R.; Abid, M. natural product-based 1,2,3-triazole/sulfonate analogues as potential chemotherapeutic agents for bacterial infections. ACS Om