Association between apolipoprotein E polymorphisms and gastric cancer in a hospital-based Turkish population

Therefore, further investigations such as expression studies and meta-analysis comprising larger sample size and detailed demographic data are necessary to identify the alleles of APOE gene associated with the risk of gastric cancer.

📌 3 Maddede Bu Makale

🎯

Amaç & Hipotez:Apolipoprotein E (ApoE) is an important secretory glycoprotein, and also a ligand for LDL receptors and ApoE receptors.

📊

Temel Bulgular & Veri:In this context, this study was conducted to evaluate the association between the genotypes of APOE and the risk of gastric cancer and also to demonstrate the allele frequencies and genotype distributions of APOE gene in a hospital-based Turkish population with gastric cancer.

💡

Sonuç & Katkı:Therefore, further investigations such as expression studies and meta-analysis comprising larger sample size and detailed demographic data are necessary to identify the alleles of APOE gene associated with the risk of gastric cancer.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Gastric Cancer · ApoE polymorphisms · Turkish population

Abstract

Apolipoprotein E (ApoE) is an important secretory glycoprotein, and also a ligand for LDL receptors and ApoE receptors. It is involved in lipid transport and catabolism, nerve regeneration, immune system regulation, and cell proliferation. Moreover, both the causative and protective effects of APOE polymorphic variants and alleles have been correlated with several diseases, including cancer types such as gastric cancer. However, to the best of our knowledge, no data are available describing the association between gastric cancer and APOE polymorphisms in the Turkish population. In this context, this study was conducted to evaluate the association between the genotypes of APOE and the risk of gastric cancer and also to demonstrate the allele frequencies and genotype distributions of APOE gene in a hospital-based Turkish population with gastric cancer. A total of 59 patients with gastric cancer and 200 healthy controls were included in this study. Results showed the absence of any statistically significant association between APOE gene polymorphisms and the risk of gastric cancer (χ2 =2.711, p=0.744), which could possibly be due to the small sample size of our study. Therefore, further investigations such as expression studies and meta-analysis comprising larger sample size and detailed demographic data are necessary to identify the alleles of APOE gene associated with the risk of gastric cancer.

Anahtar kelimeler

Gastric Cancer ApoE polymorphisms Turkish population

🔖

Bu Makaleye Atıf Yap

KORAK, T., ÜREN, N., ERGÜL, E., ŞİMŞEK, T., SAZCI, A., CANTÜRK, N. Z., UTKAN, N. Z. (2017). Association between apolipoprotein E polymorphisms and gastric cancer in a hospital-based Turkish population. İstanbul Journal of Pharmacy, Cilt: 47 - Sayı: 3, 97–100. https://ajindex.com/articles/41782

📄 Tam Metin PDF Okuyucu

Yeni Sekmede Aç ↗

↗Yeni Sekme

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (7)

Acar Çinleti B, Yardimci N, Aytürk Z, Ilhan A, Kaya G, Acar M, Koç ER, Gündüz E, Gündüz M (2015). The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease. Turk J Med Sci. 45(5):1098-105.
Alaylıoğlu M, Gezen-Ak D, Dursun E, Bilgiç B, Hanağası H, Ertan T, Gürvit H, Emre M, Eker E, Uysal Ö, Yılmazer S (2016). The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort. J Geriatr Psychiatry Neurol. 29(4):221-6.
Cetinkalp S, Karadeniz M, Erdogan M, Zengi A, Cetintas V, Tetik A, Eroglu Z, Kosova B, Ozgen AG, Saygili F, Yilmaz C (2009). Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey. J Assist Reprod Genet. 26(1):1-6.
Cibeira GH, Giacomazzi J, Aguiar E, Schneider S, Ettrich B, DE Souza CI, Camey S, Caleffi M, Weber B, Ashton-Prolla P, Moriguchi EH (2014). Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study. Mol Clin Oncol. 2(6):1009-1015.
De Feo E, Simone B, Persiani R, Cananzi F, Biondi A, Arzani D, Amore R, D’Ugo D, Ricciardi G, Boccia S (2012). A case–control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression. BMC Cancer 12, 494. Erdogan M, Eroglu Z, Kulaksizoglu M, Soner S, Tetik A, Cetinkalp S (2016). The relationship of the apolipoprotein E gene polymorphism in Turkish Type 2 Diabetic Patients with and without diabetic foot ulcers. Diabetes Metab Syndr. 10(1 Suppl 1):S30-3. Kang R, Li P, Wang T, Li X, Wei Z, Zhang Z, Zhong L, Cao L, Heckman MG, Zhang YW, Xu H, Huang C, Bu G, Chen XF (2016). Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Sci Rep. 28;6:19930. Liu YL, Zhang HM, Pan HM, Bao YH, Xue J, Wang TC, Dong XC, Li XL, Bao HG (2016). The relationship between apolipoprotein E gene ε2/ε3/ε4 polymorphism and breast cancer risk: a systematic review and meta-analysis. Onco Targets Ther. 9:1241-9.
Miller SA, Dykes DD, Polesky HF (1988). A simple salting out procedure for extractingDNA from human nucleated cells. Nucleic Acids Res. 16(3): 1215. Ni J, Shen N, Tang J, Ren K (2017). Correlation between protein kinase catalytic subunit alpha-1 gene rs13361707 polymorphism and gastric cancer susceptibility in asian populations. Oncotarget 8(40):68354-68364.
Niemi M, Kervinen K, Kiviniemi H, Lukkarinen O, Kyllo¨nen A-P, Sarkkinen MA, Savolainen MJ, KairaluomaMI, Kesanie