Dergiler / Troia Tıp Dergisi / 2022 / Cilt: 3 - Sayı: 2

Digoxin Intoxication

Sayfa
52–56
Yayın Tarihi
2022-05-31
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Our aim in this article is to summarize the effects of digoxin on the cardiovascular system and current approaches in case of possible side effects.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Digoxin is a cardiac glycoside used in the treatment of heart failure and arrhythmia.
📊
Temel Bulgular & Veri:However, it causes a decrease in heart rate due to its negative effect on the atrioventricular (AV) node.
💡
Sonuç & Katkı:Our aim in this article is to summarize the effects of digoxin on the cardiovascular system and current approaches in case of possible side effects.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Digoxin · heart failure · pharmacokinetic profile

Abstract

Digoxin is a cardiac glycoside used in the treatment of heart failure and arrhythmia. It has a positive effect on ventricular contraction. However, it causes a decrease in heart rate due to its negative effect on the atrioventricular (AV) node. The narrow therapeutic range of blood digoxin levels cause some concerns about the drug. Our aim in this article is to summarize the effects of digoxin on the cardiovascular system and current approaches in case of possible side effects.

🔖

Bu Makaleye Atıf Yap

KÜÇÜK, U., KIRILMAZ, B., AŞGÜN, H. F., AKŞİT, E. (2022). Digoxin Intoxication. Troia Tıp Dergisi, Cilt: 3 - Sayı: 2, 52–56. https://ajindex.com/articles/415699

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (14)

  1. Withering W. An Account of the Foxglove and Some of Its Medical Uses; with Practical Remarks on Dropsy and Other Diseases. London: GGJ and Robinson; 1785:232-52.
  2. Ward RE, Gheorghiade M, Young JB, Uretsky B. Economic outcomes of withdrawal of digoxin therapy in adult patients with stable congestive heart failure. J Am Coll Cardiol. 1995;26(1):93-101.
  3. Gheorghiade M, Pitt B. Digitalis Investigation Group (DIG) trial: a stimulus for further research. Am Heart J. 1997;134(1):3-12.
  4. Leor J, Goldbourt U, Rabinowitz B, et al. Digoxin and increased mortality among patients recovering from acute myocardial infarction: importance of digoxin dose. The SPRINT Study Group. Cardiovasc Drugs Ther. 1995;9(5):723-9.
  5. Ordog GJ, Benaron S, Bhasin V, Wasserberger J, Balasubramanium S. Serum digoxin levels and mortality in 5,100 patients. Ann Emerg Med. 1987;16(1):32-9.
  6. Hickey AR, Wenger TL, Carpenter VP, et al. Digoxin Immune Fab therapy in the management of digitalis intoxication: safety and efficacy results of an observational surveillance study. J Am Coll Cardiol. 1991;17(3):590-8.
  7. Taboulet P, Baud FJ, Bismuth C. Clinical features and management of digitalis poisoning--rationale for immunotherapy. J Toxicol Clin Toxicol. 1993;31(2):247-60.
  8. Antman EM, Wenger TL, Butler VP Jr, Haber E, Smith TW. Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation. 1990;81(6):1744-52.
  9. Fozzard HA, Sheets MF. Cellular mechanism of action of cardiac glycosides. J Am Coll Cardiol. 1985;5(5 Suppl A):10A-15A. Eichhorn EJ, Gheorghiade M. Digoxin. Prog Cardiovasc Dis. 2002;44(4):251-66.
  10. Eichhorn EJ, Bristow MR. Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure. Circulation. 1996;94(9):2285-96.
  11. Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle MG. Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Circulation. 1989;80(1):65-77.
  12. Wang W, Chen JS, Zucker IH. Carotid sinus baroreceptor sensitivity in experimental heart failure. Circulation. 1990;81(6):1959-66.
  13. Matsumori A, Ono K, Nishio R, et al. Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain. Circulation. 1997;96(5):1501-6.
  14. Tsutamoto T, Wada A, Maeda K, et al. Digitalis increases brain natriuretic peptide in patients