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Dergiler / Turkish Journal of Hematology / 2002 / Cilt: 19 - Sayı: 3

Stevens-Johnson syndrome-like exanthema secondary to methotrexate

M. Emre ATABEK
Ümran ÇALIŞKAN
Özgür PİRGON
Hüseyin TOL
İbrahim ERKUL
Sayfa
427–430
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Methotrexate is an antineoplastic drug used commonly in leukemia treatment.
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Temel Bulgular & Veri:Because of becoming resistant to standard doses after 1970s, it is used intermediate or high doses.
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Sonuç & Katkı:The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Nötropeni · Ölümle sonuçlanma · Stevens-Johnson sendromu

Özet

Methotrexate is an antineoplastic drug used commonly in leukemia treatment. Because of becoming resistant to standard doses after 1970s, it is used intermediate or high doses. The complications of high doses are mucositis, vomiting, dermatitis exfoliativa, B-cell dysfunction, hepatotoxicity, nephrotoxicity and bone marrow depression. There were only two studies in literature about Stevens-Johnson syndrome occuring in two patients with acute lymphocytic leukemia and non-Hodgkin lymphoma after receiving high doses methotrexate and leukoverin. We have reported a two-year-old boy patient suffering from acute lymphocytic leukemia (ALL) developed a severe skin reaction two days after administration of high dose methotrexate. The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.

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Bu Makaleye Atıf Yap

ATABEK, M. E., ÇALIŞKAN, Ü., PİRGON, Ö., TOL, H., ERKUL, İ. (2002). Stevens-Johnson syndrome-like exanthema secondary to methotrexate. Turkish Journal of Hematology, Cilt: 19 - Sayı: 3, 427–430. https://ajindex.com/articles/412998

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Kaynakça (1)

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