SavedAdd your journal

Journals / Turkish Journal of Hematology / 2002 / Cilt: 19 - Sayı: 3

Stevens-Johnson syndrome-like exanthema secondary to methotrexate

M. Emre ATABEK
Ümran ÇALIŞKAN
Özgür PİRGON
Hüseyin TOL
İbrahim ERKUL
Pages
427–430
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Methotrexate is an antineoplastic drug used commonly in leukemia treatment.
📊
Key Findings & Data:Because of becoming resistant to standard doses after 1970s, it is used intermediate or high doses.
💡
Conclusion & Impact:The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nötropeni · Ölümle sonuçlanma · Stevens-Johnson sendromu

Özet

Methotrexate is an antineoplastic drug used commonly in leukemia treatment. Because of becoming resistant to standard doses after 1970s, it is used intermediate or high doses. The complications of high doses are mucositis, vomiting, dermatitis exfoliativa, B-cell dysfunction, hepatotoxicity, nephrotoxicity and bone marrow depression. There were only two studies in literature about Stevens-Johnson syndrome occuring in two patients with acute lymphocytic leukemia and non-Hodgkin lymphoma after receiving high doses methotrexate and leukoverin. We have reported a two-year-old boy patient suffering from acute lymphocytic leukemia (ALL) developed a severe skin reaction two days after administration of high dose methotrexate. The skin lesions simulated Stevens-Johnson syndrome with ulceration of the oral mucosa and erythema multiforme-like target lesions.

🔖

Cite This Article

ATABEK, M. E., ÇALIŞKAN, Ü., PİRGON, Ö., TOL, H., ERKUL, İ. (2002). Stevens-Johnson syndrome-like exanthema secondary to methotrexate. Turkish Journal of Hematology, Cilt: 19 - Sayı: 3, 427–430. https://ajindex.com/articles/412998

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Darmstadt GL, Lane AL. Vesiculobullous disorders.In: Behrman RE, Kligman RM, Arvin AM, NelsonWE (eds). Nelson Textbook of Pediatrics. 16thed.Philadelphia: WB Saunders, 1996:1850-1. 2.Mahoney DH. Acute lymphoblastic leukemia. In:Mcmillan JA, Deangelis CD, Feigin RD, WarshawBJ (eds). Oski’s Pediatrics. Philadelphia: LippincotWilliams and Wilkins, 1999:1498-500. 3.Cohen DM, Bhattacharyya I. Cinnamon-inducedoral erythema multiformlike sensitivity reaction. JAm Dent Assoc 2000;131:929-34. 4.Cuthbert RJ, Criag JI, Ludlam CA. Stevens-John-son Syndrome associated with methotrexate treat-ment for non-Hodgkin’s lymphoma. Ulster Med J1993; 62:95-7. 5.Moe PJ, Seip M. High dose methotrexate acutelymphoblastic leukemia in childhood. Acta PaediatrScand 1978;67:256-8. 6.Green DM, Brecher ML, Blumenson LE, Grossi M,Freeman AI. The use of intermediate dose methot-rexate in increased risk childhood acute lymphob-lastic leukemia. A comparison of three versus sixcourses. Cancer 1982;50:2722-7. 7.Hani N, Casper C, Groth W, Krieg T, HunzelmannN. Stevens-Johnson syndrome-like exanthema se-condary to methotrexate histologically simulatingacute graft-versus-host disease. Eur J Dermatol2000;10:548-50.