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Dergiler / Turkish Neurosurgery / 2017 / Cilt: 27 - Sayı: 6

Topical Application of Cyclosporine Reduces Epineurial Fibrosis: Gross Post-surgical, Histopathological and Ultrastructural Analysis in a Rat Sciatic Nerve Model

Nuri Eralp ÇETİNALP
Serdar Baki ALBAYRAK
Özgür İSMAİLOĞLU
Nail Çağlar TEMİZ
İlker SOLMAZ
GAMZE TANRIÖVER
Necdet DEMİR
Sayfa
969–974
DOI
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CONClUSION: Topical cyclosporine effectively reduces epineurial scar formation on rat sciatic nerves

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Amaç & Hipotez:AIm: To investigate the anti-scarring potential of topical cyclosporine on rat sciatic nerves. mATERIAl and mEThODS: Both sciatic nerves were exposed in 24 adult male albino Wistar rats, and an abrasion injury was made on the biceps femoris close to the sciatic nerve.
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Temel Bulgular & Veri:Cotton pads soaked with cyclosporine (5 mg/mL) and saline (0.9% NaCl) were placed around the nerves for 10 minutes in the experimental group and control group, respectively.
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Sonuç & Katkı:CONClUSION: Topical cyclosporine effectively reduces epineurial scar formation on rat sciatic nerves
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

AIm: To investigate the anti-scarring potential of topical cyclosporine on rat sciatic nerves. mATERIAl and mEThODS: Both sciatic nerves were exposed in 24 adult male albino Wistar rats, and an abrasion injury was made on the biceps femoris close to the sciatic nerve. Cotton pads soaked with cyclosporine (5 mg/mL) and saline (0.9% NaCl) were placed around the nerves for 10 minutes in the experimental group and control group, respectively. All rats were sacrificed 8 weeks later and the sciatic nerves were examined. Epineurial adhesions were assessed using light and electron microscopy. Quantitative histological parameters, epineurial thickness, and scar density were evaluated in the histological investigation. RESUlTS: Significantly fewer epineurial adhesions were observed in the cyclosporine group in the post-surgical assessment, and the histopathological and ultrastructural examinations of the nerve segments than in the controls. The cyclosporine-treated animals had a statistically significant reduction in the density and quantity of epineurial scarring compared with the controls. CONClUSION: Topical cyclosporine effectively reduces epineurial scar formation on rat sciatic nerves

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Bu Makaleye Atıf Yap

ÇETİNALP, N. E., ALBAYRAK, S. B., İSMAİLOĞLU, Ö., TEMİZ, N. Ç., SOLMAZ, İ., TANRIÖVER, G., DEMİR, N. (2017). Topical Application of Cyclosporine Reduces Epineurial Fibrosis: Gross Post-surgical, Histopathological and Ultrastructural Analysis in a Rat Sciatic Nerve Model. Turkish Neurosurgery, Cilt: 27 - Sayı: 6, 969–974. https://ajindex.com/articles/405362

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