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Dergiler / Turkish Neurosurgery / 2016 / Cilt: 26 - Sayı: 6

14-3-3zeta Positive Cells Show More Tumorigenic Characters in Human Glioblastoma

Zhonghua LUO
Xiaoliang YANG
Lian-Ting MA
Zhiqun WU
Guozheng XU
Xiaofeng WANG
Weidong CAO
Sayfa
813–817
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

CONClUSION: Cells with 14-3-3zeta positive expression show more tumorigenic character and should be administered other treatments in the future.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:AIm: expression of 14-3-3zeta is upregulated in many cancer types and plays an important role in tumorigenesis.
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Temel Bulgular & Veri:Our previous studies have shown that 14-3-3zeta has a positive expression and is associated with a poor prognosis in patients with glioblastoma.
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Sonuç & Katkı:CONClUSION: Cells with 14-3-3zeta positive expression show more tumorigenic character and should be administered other treatments in the future.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

AIm: expression of 14-3-3zeta is upregulated in many cancer types and plays an important role in tumorigenesis. Our previous studies have shown that 14-3-3zeta has a positive expression and is associated with a poor prognosis in patients with glioblastoma. In this study, we investigated whether 14-3-3zeta positive cells show more tumorigenic character and stronger chemotherapy resistance. mATERIAl and mEThODS: Six human glioblastoma cells lines were derived from the 6 patients with tumor, and the cells were sorted by 14-3-3zeta expression. The cell viability, invasion, tumorigenic ability and chemotherapy resistance were compared between the 14-3-3 positive and negative expression groups. RESUlTS: 14-3-3zeta positive cells displayed oncogenic properties, more tumorigenic character, high invasiveness, tumorsphere formation ability and resistance to temozolomide chemotherapy treatment. CONClUSION: Cells with 14-3-3zeta positive expression show more tumorigenic character and should be administered other treatments in the future.

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Bu Makaleye Atıf Yap

LUO, Z., YANG, X., MA, L., WU, Z., XU, G., WANG, X., CAO, W. (2016). 14-3-3zeta Positive Cells Show More Tumorigenic Characters in Human Glioblastoma. Turkish Neurosurgery, Cilt: 26 - Sayı: 6, 813–817. https://ajindex.com/articles/404708

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