Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightRadiotherapyseems to prolong survival; however, large-scale studies are needed to establish prognostic factors.
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Özet
AIM: To share a single center experience with 27 atypical teratoid/rhabdoid tumor (AT/RT) cases, and to determine the effect ofgross total tumor resection and other clinical characteristics on the overall survival rate of AT/RT.MATERIAL and METHODS: We included 27 patients—with a histopathologically confirmed primary intracranial childhood AT/RT—who were operated in our clinic between January 2000 and December 2017. Age, sex, tumor location, disseminated disease,the presence of hydrocephalus, symptom duration till diagnosis, the extent of resection, and adjuvant radiotherapy were evaluatedfor their influence on overall survival.RESULTS: Median age at diagnosis for 27 patients was 19.1 months (7.2 months-5 years). Gross total resection was possible in 13(48.72%) patients. Except for three patients who died of perioperative complications, all patients received chemotherapy and 11received radiotherapy. In univariate analysis, male sex, older age at diagnosis (≥24 months), gross total resection, and radiotherapywere associated with overall longer survival; however, radiotherapy remained the only significant parameter in multivariate analysis.CONCLUSION: AT/RT is a rare and dreadful brain tumor that has low survival rates despite contemporary treatment. Radiotherapyseems to prolong survival; however, large-scale studies are needed to establish prognostic factors.